Tolerance to ischemia and hypoxia is reduced in aged human myocardium

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Presentation transcript:

Tolerance to ischemia and hypoxia is reduced in aged human myocardium Justin Mariani, MBBSa, Ruchong Ou, MBBSa, Michael Bailey, MSc(Stats)b, Michael Rowland, MBBS, FRACSa, Phillip Nagley, DScc, Franklin Rosenfeldt, MD, FRACSa, Salvatore Pepe, PhDa The Journal of Thoracic and Cardiovascular Surgery Volume 120, Issue 4, Pages 660-667 (October 2000) DOI: 10.1067/mtc.2000.106528 Copyright © 2000 American Association for Thoracic Surgery Terms and Conditions

Fig. 1 The recovery of trabecular contractile DF after 30 minutes of hypoxia (A) or simulated ischemia (B) is expressed as a percentage of pre-stress DF in 3 age groups. Panel C shows the percentage recovery of the DF achieved after simulated ischemia or hypoxia plotted against age as a linear function (n = 58, r 2 = 0.52, P = .0002). The Journal of Thoracic and Cardiovascular Surgery 2000 120, 660-667DOI: (10.1067/mtc.2000.106528) Copyright © 2000 American Association for Thoracic Surgery Terms and Conditions