Volume 134, Issue 3, Pages (March 2008)

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Volume 134, Issue 3, Pages 706-715 (March 2008) Immunoglobulin G4–Associated Cholangitis: Clinical Profile and Response to Therapy Amaar Ghazale, Suresh T. Chari, Lizhi Zhang, Thomas C. Smyrk, Naoki Takahashi, Michael J. Levy, Mark D. Topazian, Jonathan E. Clain, Randall K. Pearson, Bret T. Petersen, Santhi Swaroop Vege, Keith Lindor, Michael B. Farnell Gastroenterology Volume 134, Issue 3, Pages 706-715 (March 2008) DOI: 10.1053/j.gastro.2007.12.009 Copyright © 2008 AGA Institute Terms and Conditions

Figure 1 IgG4-associated sclerosing cholangitis with intrahepatic strictures mimicking PSC (A) before treatment, and (B) after 12 weeks of steroid therapy. Gastroenterology 2008 134, 706-715DOI: (10.1053/j.gastro.2007.12.009) Copyright © 2008 AGA Institute Terms and Conditions

Figure 2 Flowchart of study patients (n = 53) according to treatment groups. *Relapse rates did not differ between the surgery and steroid groups (P = .1, NS). The time to relapse was longer in the surgery group (P = .03); however, the range was wide. †Serologic relapse occurred in only 1 patient in this group (overall, 3 patients had only serologic relapse [without a biochemical relapse]). AZA, azathioprine; MM, mycophenolate mofetil. Gastroenterology 2008 134, 706-715DOI: (10.1053/j.gastro.2007.12.009) Copyright © 2008 AGA Institute Terms and Conditions

Figure 3 Kaplan–Meier curve of relapse-free survival in patients with distal (intrapancreatic) strictures only vs patients with any proximal strictures (proximal extrahepatic, intrahepatic, or both). —, Distal only (n = 27); - - -, any proximal (n = 26). *P = .02. Gastroenterology 2008 134, 706-715DOI: (10.1053/j.gastro.2007.12.009) Copyright © 2008 AGA Institute Terms and Conditions

Figure 4 Algorithm for the diagnosis and management of suspected IAC. Gastroenterology 2008 134, 706-715DOI: (10.1053/j.gastro.2007.12.009) Copyright © 2008 AGA Institute Terms and Conditions