Current Graft-versus-Host Disease–Free, Relapse-Free Survival: A Dynamic Endpoint to Better Define Efficacy after Allogenic Transplant Scott R. Solomon,

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Presentation transcript:

Current Graft-versus-Host Disease–Free, Relapse-Free Survival: A Dynamic Endpoint to Better Define Efficacy after Allogenic Transplant Scott R. Solomon, Connie Sizemore, Xu Zhang, Michelle Ridgeway, Melhem Solh, Lawrence E. Morris, H. Kent Holland, Asad Bashey Biology of Blood and Marrow Transplantation Volume 23, Issue 7, Pages 1208-1214 (July 2017) DOI: 10.1016/j.bbmt.2017.02.022 Copyright © 2017 The American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 Possible transitions in multistate model for CGRFS. Biology of Blood and Marrow Transplantation 2017 23, 1208-1214DOI: (10.1016/j.bbmt.2017.02.022) Copyright © 2017 The American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 (A) Comparison of CGRFS to conventional GRFS, DFS, and OS, (B) Gain in CGRFS due to the treatment of chronic GVHD as a dynamic event. Biology of Blood and Marrow Transplantation 2017 23, 1208-1214DOI: (10.1016/j.bbmt.2017.02.022) Copyright © 2017 The American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 3 Component events of the CGRFS endpoint. Biology of Blood and Marrow Transplantation 2017 23, 1208-1214DOI: (10.1016/j.bbmt.2017.02.022) Copyright © 2017 The American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 4 CGRFS according to (A) DRI, (B) age, (C) HCT-CI, (D) donor type, (E) conditioning intensity, and (F) stem cell source. Biology of Blood and Marrow Transplantation 2017 23, 1208-1214DOI: (10.1016/j.bbmt.2017.02.022) Copyright © 2017 The American Society for Blood and Marrow Transplantation Terms and Conditions