Luminal signal in tubuloglomerular feedback: What about potassium?

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Luminal signal in tubuloglomerular feedback: What about potassium? Volker Vallon, Hartmut Osswald, Roland C. Blantz, Scott Thomson Kidney International Volume 54, Pages S177-S179 (September 1998) DOI: 10.1046/j.1523-1755.1998.06739.x Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 1 K+-recycling, tubular reabsorption, and tubuloglomerular feedback. Changing late proximal tubular flow rate (VLP) alters predominantly the load of Na+ and Cl- to the thick ascending limb of Henle's loop (TALH) with minor changes in K+ delivery. The observed changes in early distal tubular [K+] despite significant alteration in K+-dependent reabsorption of Na+ and Cl- (indicated by line thickness) may reflect adaptation of K+ recycling: adenosine triphosphate (ATP)-sensitive K+ channels (KATP), varying their activity according to the transport-dependent metabolic status of TALH, may contribute to load-dependent tubular reabsorption and macula densa control of single-nephron glomerular filtration rate (SNGFR). Kidney International 1998 54, S177-S179DOI: (10.1046/j.1523-1755.1998.06739.x) Copyright © 1998 International Society of Nephrology Terms and Conditions