Volume 4, Issue 7, Pages (August 2018)

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Volume 4, Issue 7, Pages 669-671 (August 2018) Pityriasis rubra pilaris–like erythroderma in the setting of pembrolizumab therapy responsive to acitretin Emily Coleman, BA, Gauri Panse, MD, MBBS, Jason Haldas, MD, Scott N. Gettinger, MD, Jonathan S. Leventhal, MD JAAD Case Reports Volume 4, Issue 7, Pages 669-671 (August 2018) DOI: 10.1016/j.jdcr.2018.06.022 Copyright © 2018 American Academy of Dermatology, Inc. Terms and Conditions

Fig 1 Clinical presentation and response to treatment. A, Erythroderma with red-orange patches and dry desquamative scale at presentation. B and C, Orange-red plaques and keratoderma with waxy scale on the plantar feet and palms. D, Marked improvement of the palm after 8 weeks of treatment with acitretin and topical steroids. JAAD Case Reports 2018 4, 669-671DOI: (10.1016/j.jdcr.2018.06.022) Copyright © 2018 American Academy of Dermatology, Inc. Terms and Conditions

Fig 2 Histologic examination found epidermal acanthosis with orthokeratosis and parakeratosis, with an intact granular layer and mild spongiosis. There was a perivascular inflammatory infiltrate within the papillary dermis. (Hematoxylin-eosin stain; original magnification, ×200.) JAAD Case Reports 2018 4, 669-671DOI: (10.1016/j.jdcr.2018.06.022) Copyright © 2018 American Academy of Dermatology, Inc. Terms and Conditions