parsley is not amenable to forward genetics

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Presentation transcript:

parsley is not amenable to forward genetics

NHL25 NHL3

Innate immunity – A common theme in mammals, Drosophila and plants (1) Pathogen-associated molecular patterns (PAMP) are recognized by pattern recognition receptors and trigger expression of immune response genes (Medzhitov, R & Janeway, CA (1997) Cell 91:295-8) LPS from gram-negative bacteria PGN from gram-positive bacteria Fungal glucans, chitin, proteins Eubacterial flagellin (often) abundant structures Surface-exposed structures Not present in hosts Evolutionarily conserved Crucial to the biology of the pathogen Institut of plant biochemistry

Innate immunity – A common theme in mammals, Drosophila and plants (2) Institute of Plant Biochemistry

Acknowledgement Collaborations: Justin Lee Annette Romanski Guido Fellbrich Magdalena Krzymowska Anne Varet Sabine Rosahl Carola Geiler Thorsten Nürnberger Dierk Scheel Collaborations: Sakari Kauppinen (Novo Nordisk A/S, Denmark) Grethe Rasmussen Francine Govers (University of Wageningen, The Netherlands) Jürg Felix (FMI Basel, Switzerland) Jeff Dangl (University of North Carolina, USA) KWS Einbeck, Germany Institute of Plant Biochemistry