Urinary biomarkers in the early diagnosis of acute kidney injury

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Presentation transcript:

Urinary biomarkers in the early diagnosis of acute kidney injury W.K. Han, S.S. Waikar, A. Johnson, R.A. Betensky, C.L. Dent, P. Devarajan, J.V. Bonventre Kidney International Volume 73, Issue 7, Pages 863-869 (April 2008) DOI: 10.1038/sj.ki.5002715 Copyright © 2008 International Society of Nephrology Terms and Conditions

Figure 1 Comparison of various urinary biomarkers in cross-sectional study. Combined box and whisker and dot plot of normalized urinary MMP-9, NAG, and KIM-1 levels is shown among control (non-AKI), AKI, and UTI groups. AKI, acute kidney injury; UTI, urinary tract infection. Kidney International 2008 73, 863-869DOI: (10.1038/sj.ki.5002715) Copyright © 2008 International Society of Nephrology Terms and Conditions

Figure 2 ROC analysis for normalized urinary biomarkers in cross-sectional study ROC curves of normalized MMP-9, NAG, and KIM-1 as a single test and in combination were plotted. The greater the displacement above and to the left of the line identified, the greater the likelihood that raised values of the test will identify AKI. Kidney International 2008 73, 863-869DOI: (10.1038/sj.ki.5002715) Copyright © 2008 International Society of Nephrology Terms and Conditions

Figure 3 Pattern of urinary biomarker expression in case–control study. Graphs showing mean normalized urine KIM-1, NAG, and MMP-9 concentrations at multiple time points after cardiopulmonary bypass. Error bars are s.e. Kidney International 2008 73, 863-869DOI: (10.1038/sj.ki.5002715) Copyright © 2008 International Society of Nephrology Terms and Conditions