Figure 1. Kidney-Specific Cre/loxP Recombination.

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Figure 1. Kidney-Specific Cre/loxP Recombination. Figure 1. Kidney-Specific Cre/loxP Recombination. Cre recombinase is expressed under the control of a kidney-specific promoter (left) and two loxP sites (triangles) are inserted in the introns flanking an essential exon of a gene of interest (orange box). For simplicity, only one of two copies of the floxed gene is shown. In the kidney, Cre recombinase (brown) will be expressed and will excise the DNA sequence between the loxP sites, which will inactivate the gene. In all other tissues, Cre will not be expressed and the gene will remain active. Bent arrow indicates the transcription initiation site. Peter Igarashi JASN 2004;15:2237-2239 ©2004 by American Society of Nephrology