Human saphenous vein allograft bypass grafts: Immune response

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Presentation transcript:

Human saphenous vein allograft bypass grafts: Immune response Jeffrey P. Carpenter, MD, John E. Tomaszewski, MD Journal of Vascular Surgery Volume 27, Issue 3, Pages 492-499 (March 1998) DOI: 10.1016/S0741-5214(98)70323-4 Copyright © 1998 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 1 Fibrointimal hyperplasia. Intimal thickening partially occludes graft lumen (original magnification, 100×; hematoxylin and eosin). Journal of Vascular Surgery 1998 27, 492-499DOI: (10.1016/S0741-5214(98)70323-4) Copyright © 1998 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 2 Medial hemorrhage and necrosis. Necrotic media shows loss of nuclear staining and dissecting acute hemorrhage (original magnification, 100×; hematoxylin and eosin). Journal of Vascular Surgery 1998 27, 492-499DOI: (10.1016/S0741-5214(98)70323-4) Copyright © 1998 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 3 Capillary ingrowth. Dense capillary network infiltrating vessel wall in allograft with cellular rejection (original magnification, 100×; factor VIII immunostain). Journal of Vascular Surgery 1998 27, 492-499DOI: (10.1016/S0741-5214(98)70323-4) Copyright © 1998 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 4 Dense cellular infiltrate of vessel wall in acute rejection composed of many mononuclear cells with a smaller number of neutrophils (original magnification, 200×; hematoxylin and eosin). Journal of Vascular Surgery 1998 27, 492-499DOI: (10.1016/S0741-5214(98)70323-4) Copyright © 1998 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 5 Positive lymphoid cells with block and granular staining for TIA-1 in cytotoxic granules (original magnification, 200×; immunoperoxidase stain). Journal of Vascular Surgery 1998 27, 492-499DOI: (10.1016/S0741-5214(98)70323-4) Copyright © 1998 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 6 Positive lymphoid cells with strong staining for the T-cell marker CD3 (original magnification, 200×; immunoperoxidase stain). Journal of Vascular Surgery 1998 27, 492-499DOI: (10.1016/S0741-5214(98)70323-4) Copyright © 1998 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 7 Positive lymphoid cells with strong staining for the cytotoxic T-cell marker CD8 (original magnification, 200×; immunoperoxidase stain). Journal of Vascular Surgery 1998 27, 492-499DOI: (10.1016/S0741-5214(98)70323-4) Copyright © 1998 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions