Representative photomicrographs of morphologic changes in mouse kidneys after injection with 225Ac-labeled antibody. Representative photomicrographs of.

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Representative photomicrographs of morphologic changes in mouse kidneys after injection with 225Ac-labeled antibody. Representative photomicrographs of morphologic changes in mouse kidneys after injection with 225Ac-labeled antibody. (A through C) At 10 wk, isolated tubular cell swelling, lysis, and karyorrhexis (arrows); normal juxtaglomerular (JG) cells (arrowheads); and negative TGF-β1 staining. (D through F) At 20 wk, varying tubulolysis (arrows), increased JG cells (arrowheads), and focal TGF-β1–positive tubular and interstitial cells (*). (G through I) At 25 wk, widespread tubulolysis with empty tubular basement membrane (TBM) profiles (arrows), increased JG cells (arrowheads), and increased TGF-β1—positive cells (*). Magnification, ×400 in A and B; ×160 in C through F, H, and I. Jaspreet Singh Jaggi et al. JASN 2005;16:2677-2689 ©2005 by American Society of Nephrology