Mild vitamin A deficiency leads to inborn nephron deficit in the rat

Slides:

Advertisements

Similar presentations

M. Mizobuchi, J.L. Finch, D.R. Martin, E. Slatopolsky

Advertisements

Protein restriction in pregnancy is associated with increased apoptosis of mesenchymal cells at the start of rat metanephrogenesis Simon J.M. Welham,

Htr-9 stimulates ICAM-1 gene expression in human ASM cells.

Volume 62, Issue 6, Pages (December 2002)

Volume 61, Issue 2, Pages (February 2002)

Volume 60, Issue 4, Pages (October 2001)

Boye L. Jensen, Bianca Mann, Ole Skøtt, Armin Kurtz

Mechanical stress reduces podocyte proliferation in vitro

Volume 69, Issue 8, Pages (April 2006)

Volume 60, Issue 5, Pages (November 2001)

Volume 55, Issue 2, Pages (February 1999)

Volume 56, Issue 1, Pages (July 1999)

Modulation of the BCL-2/BAX ratio by interferon-γ and hypoxia in human peritoneal and adhesion fibroblasts Ghassan M. Saed, Ph.D., Zhongliang Jiang,

M.H.A. Baccora, P. Cortes, C. Hassett, D.W. Taube, J. Yee

Distinct functions for Ras GTPases in the control of proliferation and apoptosis in mouse and human mesangial cells B.M. Hendry, A. Khwaja, Q.Y. Qu,

Volume 71, Issue 3, Pages (February 2007)

Volume 65, Issue 4, Pages (April 2004)

Very low-density lipoprotein stimulates the expression of monocyte chemoattractant protein-1 in mesangial cells Edward G. Lynn, Yaw L. Siow, Dr Karmin.

Volume 68, Issue 4, Pages (October 2005)

Expression of inter-α-trypsin inhibitor and tumor necrosis factor-stimulated gene 6 in renal proximal tubular epithelial cells Ulf Janssen, Gareth Thomas,

Volume 55, Issue 2, Pages (February 1999)

Volume 62, Issue 5, Pages (November 2002)

Rafael Gongora, Robert P Stephan, Zhixin Zhang, Max D Cooper Immunity

Volume 63, Issue 5, Pages (May 2003)

Volume 57, Issue 6, Pages (June 2000)

Volume 59, Issue 4, Pages (April 2001)

Sri Rajalakshmi Rudrabhatla, Christie L. Mahaffey, Mark E. Mummert

Volume 64, Issue 4, Pages (October 2003)

Volume 54, Issue 2, Pages (August 1998)

Volume 54, Issue 6, Pages (January 1998)

Volume 62, Issue 3, Pages (September 2002)

Decreased Extracellular-Signal-Regulated Kinase and Increased Stress-Activated MAP Kinase Activities in Aged Human Skin In Vivo Jin Ho Chung, Sewon Kang,

Protein restriction in pregnancy is associated with increased apoptosis of mesenchymal cells at the start of rat metanephrogenesis Simon J.M. Welham,

Volume 61, Issue 1, Pages S106-S109 (January 2002)

Volume 58, Issue 2, Pages (August 2000)

Volume 59, Issue 6, Pages (June 2001)

Volume 62, Issue 5, Pages (November 2002)

Volume 65, Issue 1, Pages (January 2004)

M. Mizobuchi, J.L. Finch, D.R. Martin, E. Slatopolsky

Calcitonin receptor isoforms expressed in the developing rat kidney

Volume 59, Issue 4, Pages (April 2001)

Volume 66, Issue 5, Pages (November 2004)

Volume 65, Issue 3, Pages (March 2004)

Volume 61, Issue 6, Pages (June 2002)

Cloning of a novel gene in the human kidney homologous to rat munc13s: Its potential role in diabetic nephropathy Yong Song, Menachem Ailenberg, Mel.

Eva Balint, Cory F. Marshall, Dr Stuart M. Sprague

Volume 67, Issue 6, Pages (June 2005)

Dr Antonio Di Stefano, Sylvie Jounier, Monika Wittner

Volume 67, Issue 4, Pages (April 2005)

Volume 56, Issue 5, Pages (November 1999)

Stephan Huber, Gerald Braun, Bernd Schröppel, Michael Horster

Volume 61, Issue 5, Pages (May 2002)

Effect of asymmetric dimethylarginine on osteoblastic differentiation

Prasun K. Datta, Elias A. Lianos Kidney International

Suppression of VEGFR2 Expression in Human Endothelial Cells by Dimethylfumarate Treatment: Evidence for Anti-Angiogenic Action Markus Meissner, Monika.

Volume 56, Issue 1, Pages (July 1999)

Volume 69, Issue 2, Pages (January 2006)

Jens Gaedeke, Nancy A. Noble, Wayne A. Border Kidney International

Expression of transforming growth factor beta isoform mRNA in injured peritoneum that healed with adhesions and without adhesions and in uninjured peritoneum

Cultured human glomerular mesangial cells express the C5a receptor

Volume 56, Issue 5, Pages (November 1999)

J. Martin, T. Bowen, R. Steadman Kidney International

Volume 58, Issue 6, Pages (December 2000)

Cl- channels in basolateral TAL membranes. XVI

Triptolide is a potent suppressant of C3, CD40 and B7h expression in activated human proximal tubular epithelial cells Yuzhi Hong, Wuding Zhou, Ke Li,

Differential effects of simvastatin on mesangial cells

Nerve Growth Factor Protects Human Keratinocytes from Ultraviolet-B-Induced Apoptosis Alessandra Marconi, Cristina Vaschieri, Silvia Zanoli, Alberto.

Volume 60, Issue 5, Pages (November 2001)

Volume 66, Issue 1, Pages (July 2004)

Volume 70, Issue 1, Pages (July 2006)

Presentation transcript:

Mild vitamin A deficiency leads to inborn nephron deficit in the rat Martine Lelièvre-Pégorier, José Vilar, Marie-Laure Ferrier, Evelyne Moreau, Nicole Freund, Thierry Gilbert, Claudie Merlet-Bénichou Kidney International Volume 54, Issue 5, Pages 1455-1462 (November 1998) DOI: 10.1046/j.1523-1755.1998.00151.x Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 1 Fetal plasma retinol as a function of maternal plasma retinol at 21days of gestation in control (•) and vitamin A deficiency (VAD; ○) groups. Means ± sem per litter: r = 0.862, P < 0.001. Kidney International 1998 54, 1455-1462DOI: (10.1046/j.1523-1755.1998.00151.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 2 Number of glomeruli as a function of fetal plasma retinol in 21-day-old fetuses in control (•) and vitamin A deficiency (VAD; ○) groups: r = 0.829, N = 44, P < 0.001. Kidney International 1998 54, 1455-1462DOI: (10.1046/j.1523-1755.1998.00151.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 3 Metanephros development in vitro assessed by lectin histochemistry. Explanted metanephroi from E14 embryos from control (A) or from vitamin A deficiency (VAD; B) groups were grown for six days in a defined medium. Bar represents 200 μm. Kidney International 1998 54, 1455-1462DOI: (10.1046/j.1523-1755.1998.00151.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 4 In vitro development of control and vitamin A deficient (VAD) metanephroi. Explanted metanephroi from embryonic day 14 (E14) embryos from control or VAD females were grown for six days in a defined medium in the presence or absence of 100nm retinoic acid (RA). (A) Growth was assayed by total protein content determination. (B) Differentiation was analyzed by counting the total number of glomeruli present within the metanephroi. #P < 0.001 as compared to paired controlateral metanephros. x*P < 0.001, as compared to the control group. Kidney International 1998 54, 1455-1462DOI: (10.1046/j.1523-1755.1998.00151.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 5 Product analysis of RT-PCR for c-ret mRNA. (A) Metanephroi from 15-day-old embryos from control and VAD females. (B) Pairs of metanephroi from 14-day-old embryos from control females cultured for six days in the presence or absence of 100nm retinoic acid. Two percent agarose gel stained with ethidium bromide revealed the c-ret (442bp) and the β actin control (504bp) bands. Blots are representative of experiments repeated five times (A) and three times (B). The amount of mRNA in the different experimental groups was quantified by scanning densitometry and expressed as percent of control. Kidney International 1998 54, 1455-1462DOI: (10.1046/j.1523-1755.1998.00151.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Kidney International 1998 54, 1455-1462DOI: (10. 1046/j. 1523-1755 Kidney International 1998 54, 1455-1462DOI: (10.1046/j.1523-1755.1998.00151.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Kidney International 1998 54, 1455-1462DOI: (10. 1046/j. 1523-1755 Kidney International 1998 54, 1455-1462DOI: (10.1046/j.1523-1755.1998.00151.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Kidney International 1998 54, 1455-1462DOI: (10. 1046/j. 1523-1755 Kidney International 1998 54, 1455-1462DOI: (10.1046/j.1523-1755.1998.00151.x) Copyright © 1998 International Society of Nephrology Terms and Conditions