Framework for integrating taxonomic and metabolomic data.

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Framework for integrating taxonomic and metabolomic data. Framework for integrating taxonomic and metabolomic data. Species composition is first used to predict the metagenome’s gene content, which is then paired with reaction information to estimate the community metabolic potential (CMP) for each sample and metabolite. Variation in predicted CMP scores is compared to variation in measured metabolite abundances (using pairwise differences) to identify well-predicted metabolites. A perturbation-based approach is used to additionally identify key species, gene, and reaction contributors to CMP scores. Cecilia Noecker et al. mSystems 2016; doi:10.1128/mSystems.00013-15