Enrichment of microbial functions with elevated triclosan.

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Enrichment of microbial functions with elevated triclosan. Enrichment of microbial functions with elevated triclosan. (a) Overrepresented functional capabilities among triclosan-related species (results of GSEA [42, 43]). Significantly overrepresented modules are grouped based on KEGG (38) functional categories. (b) Positive relationships between log2 1 + x-transformed gene copies per million (CPM) and triclosan levels (ng g−1 dust) for the most enriched module, the mtrAB transcriptional regulators. Bars represent individual rooms, stratified based on the proportions of species-specific annotations. Marker colors for triclosan levels are the same as in Fig. 1d. (c and d) Bar plots as in panel b for the two functions with the highest positive Spearman rank correlation coefficients with triclosan (ρ = 0.29 and 0.23, respectively). Ashkaan K. Fahimipour et al. mSystems 2018; doi:10.1128/mSystems.00200-18