UK-396082 improves survival. UK-396082 improves survival. Following SNx, rats were divided into SNx untreated (disease, n=24; half those remaining were.

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UK-396082 improves survival. UK-396082 improves survival. Following SNx, rats were divided into SNx untreated (disease, n=24; half those remaining were euthanized at day 35), SNx treated from day 14 (prevention, n=12), and SNx treated from day 35 (reversal, n=12). (A) Cumulative survival was determined when animals were terminated because of signs of entering end-stage renal failure. Percentage value (in parentheses) for the late therapy/reversal group was calculated against those reaching day 35 and starting therapy. (B) Because 55% of animals did not reach this point, 24 untreated animals that reached day 35 were randomly assigned into two groups: 12 continuing on to no treatment and 12 receiving UK-396082. Survival was determined as before. Treatment commencement points are shown by black arrows, and the percentage survival to day 60 is shown.*P<0.05 and **P<0.01 (log-rank test) indicate significance against SNx animals. John M. Atkinson et al. JASN 2015;26:1925-1937 ©2015 by American Society of Nephrology