UMOD and ACSM2A expressions correlate with renal function.

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UMOD and ACSM2A expressions correlate with renal function. UMOD and ACSM2A expressions correlate with renal function. The expressions of (A) UMOD and (F) ACSM2A correlate with eGFR in tubule samples. The x axes represent eGFR (ml/min per 1.73 m2), whereas the y axes represent the normalized gene expression values of the transcript. Each dot represents transcript levels and eGFR values from a single kidney sample. The lines are the fitted correlation value (Pcorr, P value after Benjamini-Hochberg multiple testing correction). Immunohistochemistry of the samples with low and high mRNA expression showed differences of (B–E) the UMOD and (G–J) the ACSM2A expression on protein level. Scale bars, 50 μm. Nora Ledo et al. JASN 2015;26:692-714 ©2015 by American Society of Nephrology