Dominant T cells in idiopathic nephrotic syndrome of childhood

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Presentation transcript:

Dominant T cells in idiopathic nephrotic syndrome of childhood Carola Frank, Martin Herrmann, Stefany Fernandez, Diemuth Dirnecker, Michael Böswald, Wasilis Kolowos, Hans Ruder, Johannes- Peter Haas, M.D. Kidney International Volume 57, Issue 2, Pages 510-517 (October 2000) DOI: 10.1046/j.1523-1755.2000.00870.x Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 1 Overview of CDR3 analyses of TCR β;-chains from peripheral T cells and clinical data of idiopathic nephrotic syndrome (INS) patients and controls. The year of birth is indicated in parentheses. The HLA-DR typing and the EBV status are given in column 1. Abbreviations are: AD, active disease; C, cyclosporine A; E, endoxan; F, FK506; FR, frequent relapsing; FSGS, focal segmental glomerulus sclerosis; IM, initial manifestation; IR, infrequent relapsing; K, control; M, methotrexate; MCNS, minimal change nephrotic syndrome; N, no drugs; NB, no biopsy; NHD, normal healthy donor; P, patient; RM, remission; S, steroids; SD, steroid dependent; SS, steroid sensitive. Symbols are: (▪) T-cell expansions found by CDR3 spectratyping; (○) cloned and sequenced CDR3 fragments. Kidney International 2000 57, 510-517DOI: (10.1046/j.1523-1755.2000.00870.x) Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 2 T cell receptor (TCR) β;-chain CDR3 spectratype histograms from 20 Vβ; gene families of peripheral T cells isolated from patient P1 at three time points. Upper panel, 0 months; intermediate panel, 32 months; and lower panel, 37 months. Time points refer to data presented in Figure 1. Kidney International 2000 57, 510-517DOI: (10.1046/j.1523-1755.2000.00870.x) Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 3 TCR β;-chain CDR3 spectratype histograms (Vβ; 16) of peripheral T cells isolated from patient P1 at eight time points over a three years period. Time points refer to data presented in Figure 1. The clonally expanded T cells are shown to persist for the entire observation period with the strongest skewing at 12 month during a course of active disease. Kidney International 2000 57, 510-517DOI: (10.1046/j.1523-1755.2000.00870.x) Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 4 Comparison of TCR β;-chain CDR3 spectratype histograms of isolated CD4-positive and CD4-negative T cells isolated from peripheral blood of frequently relapsing INS patient (P51 and P42). Upper panel, patient P51 (3 months; Oct. 96); lower panel, patient P42 (4 months; Oct. 96). Kidney International 2000 57, 510-517DOI: (10.1046/j.1523-1755.2000.00870.x) Copyright © 2000 International Society of Nephrology Terms and Conditions