Biclonal Non-small Cell Lung Cancer in Disseminated Tumor Cells and Tissue Anna Puggina, MSc, Verena Kümmerlen, MD, Korinna Jöhrens-Leder, MD, Ulrich.

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Biclonal Non-small Cell Lung Cancer in Disseminated Tumor Cells and Tissue Anna Puggina, MSc, Verena Kümmerlen, MD, Korinna Jöhrens-Leder, MD, Ulrich Keilholz, MD, Alberto Fusi, MD Journal of Thoracic Oncology Volume 7, Issue 7, Pages 1202-1203 (July 2012) DOI: 10.1097/JTO.0b013e318257095a Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 1 Histology of the tumor: (A), primary pulmonary carcinoma (hematoxylin and eosin staining); (B), liver metastasis with extensive necrosis (hematoxylin and eosin staining); (C), gastric metastasis. The primary pulmonary carcinoma exhibited histomorphological features of a squamous carcinoma with keratinization (A). The liver metastasis showed an increased nuclear polymorphism with bizarre nuclei accompanied by extensive necrotic areas. The squamous differentiation was still visible with several keratin pearls (B). The metastasis in the stomach exhibited features of a squamous carcinoma without signs of keratinization (C). The nuclear polymorphism is similar to the one observed in the primary tumor. Journal of Thoracic Oncology 2012 7, 1202-1203DOI: (10.1097/JTO.0b013e318257095a) Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions