John H. Lemmer, MDa, George J. Despotis, MDb

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Presentation transcript:

Antithrombin III concentrate to treat heparin resistance in patients undergoing cardiac surgery John H. Lemmer, MDa, George J. Despotis, MDb The Journal of Thoracic and Cardiovascular Surgery Volume 123, Issue 2, Pages 213-217 (February 2002) DOI: 10.1067/mtc.2002.119060 Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 1 Scattergraph showing the apparent lack of correlation between kaolin ACT duration and AT activity after adminstration of greater than 600 U/kg heparin in 53 patients (r = 0.01). The Journal of Thoracic and Cardiovascular Surgery 2002 123, 213-217DOI: (10.1067/mtc.2002.119060) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 2 In 53 heparin-resistant patients the administration of AT concentrate (500 U in 45 patients and 1000 U in 8 patients) caused prolongation of the mean kaolin ACT from 492 to 798 seconds. This was associated with an increase in the slope of the HDRR value from 36.5 to 69.3 s·–1·mL–1. The Journal of Thoracic and Cardiovascular Surgery 2002 123, 213-217DOI: (10.1067/mtc.2002.119060) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions