Recurrence after low-dose radioiodine ablation and recombinant human thyroid- stimulating hormone for differentiated thyroid cancer (HiLo): long-term results.

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Presentation transcript:

Recurrence after low-dose radioiodine ablation and recombinant human thyroid- stimulating hormone for differentiated thyroid cancer (HiLo): long-term results of an open-label, non-inferiority randomised controlled trial Hakim-Moulay Dehbi, PhD, Ujjal Mallick, FRCR, Jonathan Wadsley, FRCR, Kate Newbold, FRCR, Clive Harmer, FRCR, Prof Allan Hackshaw, MSc The Lancet Diabetes & Endocrinology Volume 7, Issue 1, Pages 44-51 (January 2019) DOI: 10.1016/S2213-8587(18)30306-1 Copyright © 2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Terms and Conditions

Figure 1 Trial profile rhTSH=recombinant human thyroid-stimulating hormone. *No information available after randomisation. The Lancet Diabetes & Endocrinology 2019 7, 44-51DOI: (10.1016/S2213-8587(18)30306-1) Copyright © 2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Terms and Conditions

Figure 2 Kaplan-Meier curves showing risk of recurrence during follow-up (A) Kaplan-Meier curve of risk of recurrence according to radioactive iodine dose (3·7 GBq or 1·1 GBq). (B) Kaplan-Meier curve of risk of recurrence according to preparation for ablation with recombinant human thyroid-stimulating hormone (rhTSH) or thyroid hormone withdrawal. Kaplan-Meier curves appear to separate after about 7 years but there are only two events in total from this point. At 7 years, recurrence rates were 5·0% (95% CI 2·5–10·0) with thyroid hormone withdrawal and 8·3% (95% CI 4·5–15·3) with rhTSH, with overlapping confidence intervals. The Lancet Diabetes & Endocrinology 2019 7, 44-51DOI: (10.1016/S2213-8587(18)30306-1) Copyright © 2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Terms and Conditions