The insulin tolerance test at week 18. The insulin tolerance test at week 18. Blood glucose levels were not lowered by insulin in rats receiving F with or without HCTZ, consistent with insulin resistance. In contrast, KCL and allopurinol treatment improve the insulin response similar to that observed with the normal diet group. Data are means ± SD. P at least <0.05 *versus normal diet, &versus fructose diet, and $versus F+HCTZ. Sirirat Reungjui et al. JASN 2007;18:2724-2731 ©2007 by American Society of Nephrology