Volume 61, Issue 6, Pages (June 2002)

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Volume 61, Issue 6, Pages 1980-1985 (June 2002) Renal tubular damage detected by dynamic micro-MRI with a dendrimer-based magnetic resonance contrast agent Hisataka Kobayashi, Satomi Kawamoto, Sang-Kyung Jo, Noriko Sato, Tsuneo Saga, Akira Hiraga, Junji Konishi, Susan Hu, Kaori Togashi, Martin W. Brechbiel, Robert A. Star Kidney International Volume 61, Issue 6, Pages 1980-1985 (June 2002) DOI: 10.1046/j.1523-1755.2002.00364.x Copyright © 2002 International Society of Nephrology Terms and Conditions

Figure 1 Typical serial, two-dimensional, reconstructed contrast-enhanced dynamic micro-magnetic resonance (micro-MR) images of the normal (BUN 21.2 and creatinine 0.3;A), mildly damaged (BUN 31.3 and creatinine 0.4;B), moderately damaged (BUN 116 and creatinine 0.6;C), and severely damaged (BUN 269 and creatinine 1.9;D) kidney with 0.03 mmol/kg of G4D-(1B4M-Gd)64. Images are labeled with midpoint of the imaging acquisition cycle Kidney International 2002 61, 1980-1985DOI: (10.1046/j.1523-1755.2002.00364.x) Copyright © 2002 International Society of Nephrology Terms and Conditions

Figure 2 Comparison of micro-MR image (left) and H&E stained section of kidney (right). The cortex, outer stripe (OS) and inner stripe (IS) of the outer medulla, and urinary space/inner medulla (IM) are labeled. Radial spikes (medullary rays) that extend from the outer strip into the superficial cortex are indicated by white arrows. Kidney International 2002 61, 1980-1985DOI: (10.1046/j.1523-1755.2002.00364.x) Copyright © 2002 International Society of Nephrology Terms and Conditions

Figure 3 Correlation between the grading of serial dynamic micro-MRI of the kidney after injection of G4-(1B4M-Gd)64 and BUN (A) and creatinine (B). Note that both BUN and creatinine values are displayed on a log scale. Kidney International 2002 61, 1980-1985DOI: (10.1046/j.1523-1755.2002.00364.x) Copyright © 2002 International Society of Nephrology Terms and Conditions