VEGFC treatment improves kidney histology and survival in Cys1cpk/cpk mice. VEGFC treatment improves kidney histology and survival in Cys1cpk/cpk mice.

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VEGFC treatment improves kidney histology and survival in Cys1cpk/cpk mice. VEGFC treatment improves kidney histology and survival in Cys1cpk/cpk mice. (A) Outline of experimental strategy. (B) Representative images showing overall appearance of kidneys from Cys1+/+ and Cys1cpk/cpk mice given either vehicle or VEGFC. Bar is 0.5 cm for each panel. (C) Assessment of kidney/body wt ratio and (D) BUN concentration. (E–H) Representative images of periodic acid–Schiff-stained kidney sections obtained from Cys1+/+ and Cys1cpk/cpk mice given either vehicle or VEGFC. Bar represents 50 µm in each panel, g, glomerulus; * shows dilated tubule. (I) Image J particle analysis of images of whole kidneys under a dissection microscope to determine the average area of individual cysts. (J) Survival analysis of Cys1cpk/cpk mice administered either vehicle or VEGFC. n=7 to n=11 in each group for A–I, n=6 for J, data are presented as mean±SEM. *P<0.05; **P<0.01; and ***P<0.001 between groups. Jennifer L. Huang et al. JASN 2016;27:69-77 ©2016 by American Society of Nephrology