Personalized Medicine

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Presentation transcript:

Personalized Medicine What is Personalized Medicine ?

Personalized Medicine “One size fits all” model Personalized medicine An extension of traditional medicine A focus on genetic map and proteomics “Personal” treatment

Personalized Medicine Go with Tumor Chen Wanna 10301010094 Ma Linxiaoxi 10301010092

SHIVA trial

Applications Disease-causing mutation test --to prevent cancers Cancer prevention

Applications Targeted therapy HER2 (Chromosome17q12-21.32) Trastuzumab/Herceptin Choosing effective drugs Reducing the dose and waste of medicine Avoiding undesirable side effects

Applications Minimal residual disease tests(MRD) --to quantify residual cancer Medication or surgery on tumor Detecting the special protein markers on the tumor cells Finding the existence of tumor cells not cleaned absolutely

Problems Genetic discrimination Rising cost of treatment Medication safety

References http://en.wikipedia.org/wiki/Personalized_medicine http://www.personalizedmedicine.com/ http://baike.baidu.com/view/5731979.htm Hong K W, Oh B. Overview of personalized medicine in the disease genomic era[J]. BMB Rep, 2010,43(10):643-648. Garcia I, Kuska R, Somerman M J. Expanding the Foundation for Personalized Medicine: Implications and Challenges for Dentistry[J]. J Dent Res, 2013. Le Tourneau C, Kamal M, Trédan O, etal. Designs and challenges for personalized medicine studies in oncology: focus on the SHIVA trial[J]. Target Oncol. 2012, 7(4):253-65. Company Logo

Variability is the law of life, and as no two faces are the same, so no two bodies are alike, and no two individuals react alike and behave alike under the abnormal conditions we know as disease. --Sir William Osler (1849-1919)