Helmut Laufs, Peter Andrija Nigrovic, MD, Lynda C

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Presentation transcript:

Giant Cell Myocarditis in a 12-Year-Old Girl With Common Variable Immunodeficiency Helmut Laufs, Peter Andrija Nigrovic, MD, Lynda C. Schneider, MD, Hans Oettgen, MD, PhD, Pedro del Nido, MD, Ivan P.G. Moskowitz, MD, PhD, Elizabeth Blume, MD, Antonio R. Perez-Atayde, MD Mayo Clinic Proceedings Volume 77, Issue 1, Pages 92-96 (January 2002) DOI: 10.4065/77.1.92 Copyright © 2002 Mayo Foundation for Medical Education and Research Terms and Conditions

Figure 1 Left, Cut section of explanted heart with thickened and mottled myocardium, widespread light tan nodules measuring up to 3 mm (arrows), and focal areas of necrosis and hemorrhage. Center and right, Idiopathic giant cell myocarditis with a prominent inflammatory infiltrate consisting of mononuclear cells, lymphocytes, numerous eosinophils forming small cellular aggregates, and multinucleated giant cells (arrows, right) (hematoxylineosin stain). Mayo Clinic Proceedings 2002 77, 92-96DOI: (10.4065/77.1.92) Copyright © 2002 Mayo Foundation for Medical Education and Research Terms and Conditions

Figure 2 Immunoperoxidase reaction of the myocardial biopsy specimen with markers for CD68 (antihistiocyte antibody), CD3 (common T-cell antibody), and CD20 (anti-B-cell antibody). Prominent CD68+ histiocytic infiltrate, including CD68+ giant cells (CD68, arrows), numerous T cells (CD3), and rare B cells (CD20, arrows) (hematoxylin counterstain). Mayo Clinic Proceedings 2002 77, 92-96DOI: (10.4065/77.1.92) Copyright © 2002 Mayo Foundation for Medical Education and Research Terms and Conditions