Volume 77, Issue 1, Pages (January 2010)

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Date of download: 6/21/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Improving Glucose Metabolism With Resveratrol in.

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Volume 77, Issue 1, Pages 23-28 (January 2010) Combined effects of ghrelin and higher food intake enhance skeletal muscle mitochondrial oxidative capacity and AKT phosphorylation in rats with chronic kidney disease Rocco Barazzoni, XinXia Zhu, Mark DeBoer, Rakesh Datta, Michael D. Culler, Michela Zanetti, Gianfranco Guarnieri, Daniel L. Marks Kidney International Volume 77, Issue 1, Pages 23-28 (January 2010) DOI: 10.1038/ki.2009.411 Copyright © 2010 International Society of Nephrology Terms and Conditions

Figure 1 Mitochondrial enzyme activities. Skeletal muscle activities of cytochrome c oxidase (COX) (a) and citrate synthase (CS) (b) in the experimental groups; *P<0.05. Ghr, ghrelin; Neph, nephrectomy; PF, pair-feeding; S, saline. Kidney International 2010 77, 23-28DOI: (10.1038/ki.2009.411) Copyright © 2010 International Society of Nephrology Terms and Conditions

Figure 2 Mitochondrial biogenesis and lipid metabolism regulators. Skeletal muscle transcript levels of peroxisome proliferator-activated receptor-γ coactivator 1-α (a; PGC1-α), peroxisome proliferator-activated receptor-γ coactivator 1-β (b; PGC1-β), mitochondrial transcription factor A (c; mTFA), peroxisome proliferator-activated receptor-α (d; PPAR-α) in the experimental groups; *P<0.05. Ghr, ghrelin; Neph, nephrectomy; PF, pair-feeding; S, saline. Kidney International 2010 77, 23-28DOI: (10.1038/ki.2009.411) Copyright © 2010 International Society of Nephrology Terms and Conditions

Figure 3 Muscle triglycerides and AKT phosphorylation. Skeletal muscle triglycerides (a) and the ratio (P/T) of phosphorylated (P) to total (T) AKT protein (b) in the experimental groups. Representative bands from western blotting for P- and T-AKT are shown under each bar. *P<0.05. Ghr, ghrelin; Neph, nephrectomy; PF, pair-feeding; S, saline. Kidney International 2010 77, 23-28DOI: (10.1038/ki.2009.411) Copyright © 2010 International Society of Nephrology Terms and Conditions