RevAMPing Mitochondrial Shape to Live Longer

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RevAMPing Mitochondrial Shape to Live Longer Lena Pernas, Luca Scorrano Cell Metabolism Volume 26, Issue 6, Pages 805-806 (December 2017) DOI: 10.1016/j.cmet.2017.11.010 Copyright © 2017 Terms and Conditions

Figure 1 Model for Longevity Mediated by Mitochondrial Fusion and Metabolic Rewiring Low energy states such as dietary restriction and AMPK activation require mitochondrial elongation by the outer mitochondrial fusion GTPase fzo-1 in peripheral tissues and a boost in fatty acid oxidation in mitochondria and peroxisomes to mediate lifespan extension. Cell Metabolism 2017 26, 805-806DOI: (10.1016/j.cmet.2017.11.010) Copyright © 2017 Terms and Conditions