Impact of the Direction of HLA Mismatch on Transplantation Outcomes in Single Unrelated Cord Blood Transplantation Junya Kanda, Yoshiko Atsuta, Atsushi.

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Presentation transcript:

Impact of the Direction of HLA Mismatch on Transplantation Outcomes in Single Unrelated Cord Blood Transplantation Junya Kanda, Yoshiko Atsuta, Atsushi Wake, Tatsuo Ichinohe, Minoko Takanashi, Yasuo Morishima, Shuichi Taniguchi, Satoshi Takahashi, Hiroyasu Ogawa, Kazuteru Ohashi, Yuju Ohno, Nobuyuki Aotsuka, Yasushi Onishi, Koji Kato, Tokiko Nagamura-Inoue, Yoshinobu Kanda Biology of Blood and Marrow Transplantation Volume 19, Issue 2, Pages 247-254 (February 2013) DOI: 10.1016/j.bbmt.2012.09.017 Copyright © 2013 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 OS of total patients (A) and patients grouped according to HLA MM category (B). GVH0 HVG0, HLA match in both the GVH and HVG directions; GVH12 HVG0, antigen MMs in the GVH direction and 0 MMs in the HVG direction; GVH0 HVG12, 1 or 2 antigen MMs in the HVG direction and 0 MM in the GVH direction; GVH1 HVG1, 1 antigen MM in both the GVH and HVG directions at the same locus; GVH2 HVG2, 2 antigen MMs in both the GVH and HVG directions. Biology of Blood and Marrow Transplantation 2013 19, 247-254DOI: (10.1016/j.bbmt.2012.09.017) Copyright © 2013 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 Relapse and NRM. Biology of Blood and Marrow Transplantation 2013 19, 247-254DOI: (10.1016/j.bbmt.2012.09.017) Copyright © 2013 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 3 Neutrophil and platelet engraftment. Biology of Blood and Marrow Transplantation 2013 19, 247-254DOI: (10.1016/j.bbmt.2012.09.017) Copyright © 2013 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 4 Acute and chronic GVHD. Biology of Blood and Marrow Transplantation 2013 19, 247-254DOI: (10.1016/j.bbmt.2012.09.017) Copyright © 2013 American Society for Blood and Marrow Transplantation Terms and Conditions