Thrombus-free, human endothelial surface in the midregion of a Dacron vascular graft in the splanchnic venous circuit—Observations after nine months of.

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Thrombus-free, human endothelial surface in the midregion of a Dacron vascular graft in the splanchnic venous circuit—Observations after nine months of implantation Pauline K. Park, MD 1, Bruce E. Jarrell, MD 1, Stuart K. Williams, PhD 1, Thomas L. Carter, MD 1, Deborah G. Rose, BS 1, Antonio Martinez-Hernandez, MD 2, R.Anthony Carabasi, MD 1 Journal of Vascular Surgery Volume 11, Issue 3, Pages 468-475 (March 1990) DOI: 10.1016/0741-5214(90)90248-9 Copyright © 1990 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 1 Phlebogram 9 months after surgery showing progressive stenosis of the upper one half of the graft. The distorted external rings of the graft can be clearly seen, and compared to the luminal area in the anterior-posterior view. The widely patent mesenteric anastomosis is not shown on this view. Journal of Vascular Surgery 1990 11, 468-475DOI: (10.1016/0741-5214(90)90248-9) Copyright © 1990 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 2 Light photomicrographs demonstrating A, the luminal endothelium and myointimal region and B, the granulation tissue surrounding the Dacron fibers (arrows). (Hematoxylineosin stain; original magnification × 10.) Journal of Vascular Surgery 1990 11, 468-475DOI: (10.1016/0741-5214(90)90248-9) Copyright © 1990 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 3 A, Higher power view of luminal surface showing a continuous monolayer of flattened cells consistent with endothelium. (original magnification × 50.) B, Higher power view of the perigraft tissue. Note the Dacron fibers (arrows), with occasional foreign body giant cells, and multiple small capillaries in the granulation tissue (small arrow). (Original magnification × 40.) Journal of Vascular Surgery 1990 11, 468-475DOI: (10.1016/0741-5214(90)90248-9) Copyright © 1990 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 4 A, The lumen of the graft is covered by a continuous layer of flattened cells reacting with antibodies to factor VIII—related antigen. The smooth muscle cells and fibroblasts are negative. (Counterstained with hematoxylin; original magnification × 200.) B, The endothelium lining granulation tissue capillaries is strongly positive with antibodies to factor VIII—related antigen. Notice that the immediately adjacent cells (arrows) are negative. (Counterstained with hematoxylin; original magnification × 200.) Journal of Vascular Surgery 1990 11, 468-475DOI: (10.1016/0741-5214(90)90248-9) Copyright © 1990 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 5 Luminal endothelium with typical cobblestone morphology (Bar = 10 μm; original magnification, × 1000). Journal of Vascular Surgery 1990 11, 468-475DOI: (10.1016/0741-5214(90)90248-9) Copyright © 1990 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 6 A, The lining cells have a flattened cytoplasm with intermittent deposits of basement membrane—like structures (arrow). The immediate subendothelial region contains a loose extracellular matrix and poorly differentiated mesenchymal cells (magnification, × 21,000). B, An injured endothelial cell, “rounded”, detached from the adjacent endothelium, and surrounded by inflammatory cells, (magnification, × 3200.) Journal of Vascular Surgery 1990 11, 468-475DOI: (10.1016/0741-5214(90)90248-9) Copyright © 1990 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions