Granules defined by timing of biosynthesis of their characteristic proteins. Granules defined by timing of biosynthesis of their characteristic proteins.

Slides:

Advertisements

Similar presentations

Nadia Goodwin & Missy Walker

Advertisements

Examination of bone marrow aspirates

ERYTHROPOEISIS RBC Basophilic Polychroma- Orthochroma- Hemocytoblast

Haematopoiesis Lab 1.

Anatomy & Neurobiology ANA 812 Hematopoeisis Stephanie Gong Josh Minix Jenny Olges David Waespe.

Hematology Laboratory 1 2/4/14

Hematopoietic System Kristine Krafts, M.D..

Hematopoiesis Simplified: Part 1 Erythropoiesis

20,000 GENES IN HUMAN GENOME; WHAT WOULD HAPPEN IF ALL THESE GENES WERE EXPRESSED IN EVERY CELL IN YOUR BODY? WHAT WOULD HAPPEN IF THEY WERE EXPRESSED.

Histology for Pathology Hematopoietic Elements

B. Eosinophil Peripheral Blood Erythrocytes = RBCs NO NUCLEUS Contain hemoglobin.

Univ of Minn, Hematography Plus. umn

Endocrinology: study of hormones Gland Transport Target Cell Hormone General Features of the endocrine system:

Transcription: Synthesizing RNA from DNA

Acute Myeloid Leukemias (AML)

Chapter 12 Leukopoiesis.

PHYSIOLOGY OF LEUKOCYTES.. Function of leukocytes 1. Protective 1. Protective 2. Transport 2. Transport 3. Metabolic 3. Metabolic 4. Regenerator 4. Regenerator.

ABNORMAL LEUKOCYTES AND ERYTHROCYTES

Complexities of Gene Expression Cells have regulated, complex systems –Not all genes are expressed in every cell –Many genes are not expressed all of.

CD11b is a therapy resistance– and minimal residual disease–specific marker in precursor B-cell acute lymphoblastic leukemia by Peter Rhein, Rita Mitlohner,

Chronic myeloid leukaemia Cancer of granulocyte production Too many (non functioning) granulocytes are produced Bone marrow is overcrowded with ineffective.

Correct interpretation of prepheral blood smear

Protein Synthesis The process of protein synthesis is explained by the central dogma of molecular biology, which states that: DNA  RNA  Proteins How.

MLAB Hematology Keri Brophy-Martinez

Chapter 6 Hematopoiesis

GROUP 2 DNA TO PROTEIN. 9.1 RICIN AND YOUR RIBOSOMES.

MiRNA-130a regulates C/EBP-ε expression during granulopoiesis by Maria T. Larsen, Mattias Häger, Andreas Glenthøj, Fazila Asmar, Stine N. Clemmensen, Helena.

HOW PROTEINS ARE MADE BY THE CELL

MLAB Hematology Keri Brophy-Martinez

Post-mitotic pool (6.5 days)

WBCs / Leukocytes By Dr Sunita Mittal.

BTY100-Lec#4.2 DNA to Protein (Central Dogma).

Gene therapy: efficient targeting of hematopoietic stem cells

209. Use of Helicobacter pyroli Neutrophil Activating Protein (NAP) as an Immune- Modulatory Agent To Enhance the Efficacy of Oncolytic Adenovirus Therapy.

(3) Gene Expression Gene Expression (A) What is Gene Expression?

“Vitamin hypothesis”: explanation for allergy increase?

DNA Test Review.

Diamond-Blackfan anemia: erythropoiesis lost in translation

A Clinical Evaluation of the International Lymphoma Study Group Classification of Non-Hodgkin's Lymphoma Blood Volume 89(11): June 1, 1997 ©1997.

PHYSIOLOGY OF LEUKOCYTES. BLOOD TYPES

Cell Signaling.

Functional neutrophils from human ES cells

by Carsten U. Niemann, Magnus Åbrink, Gunnar Pejler, Rikke L

Mutation Analysis of the Rearranged Immunoglobulin Heavy Chain Genes of Marginal Zone Cell Lymphomas Indicates an Origin From Different Marginal Zone B.

Telomerase regulation in HTLV-I infection

Acute promyelocytic leukemia, microgranular variant

A Zero-Knowledge Based Introduction to Biology

Basophils take a slice of IRF8 pie

MicroRNAs: regulators of gene expression and cell differentiation

New checkpoint of the coagulant phenotype

by Douglas D. Ross, Judith E. Karp, Tar T. Chen, and L. Austin Doyle

ROCK and Rho(ll) in bone marrow

by Véronique Le Cabec, Jero Calafat, and Niels Borregaard

The transcriptional program of terminal granulocytic differentiation

The Bactericidal/Permeability-Increasing Protein (BPI) Is Present in Specific Granules of Human Eosinophils by Jero Calafat, Hans Janssen, Anton Tool,

Yang et al. SALL4 is a key regulator of survival and apoptosis in human leukemic cells. Blood. 2008;112(3):805–813. Blood Volume 114(14): October.

Protein Synthesis Lecture 5

Erythroid maturation.

Gene Expression Activation of a gene to transcribe DNA into RNA.

The Bare Lymphocyte Syndrome: Molecular Clues to the Transcriptional Regulation of Major Histocompatibility Complex Class II Genes Angela DeSandro, Uma.

K-Means clustering of protein and mRNA expression patterns after PPAR agonists treatments. k-Means clustering of protein and mRNA expression patterns after.

BLOOD PHYSIOLOGY White Blood Cells (WBC) Dr. Nervana Mostafa.

Alternative RNA Splicing

Chapter 10 – The Gene and Protein Synthesis

Vijayasaradhi Setaluri, Ph D Journal of Investigative Dermatology

by Pierre Sesques, and Nathalie A. Johnson

NOTCH1 and MYC regulate leukemia cell growth.

Neutrophils, from Marrow to Microbes

Presentation transcript:

Granules defined by timing of biosynthesis of their characteristic proteins. Granules defined by timing of biosynthesis of their characteristic proteins. The granules formed at any given stage of maturation of neutrophil precursors will be composed of the granule proteins synthesized at that time. The different subsets of granules identified are the result of differences in the biosynthetic windows of the various granule proteins during maturation and not the result of specific sorting between individual granule subsets. When the formation of granules ceases, secretory vesicles will form337 (this point has not yet been proven). The control of biosynthesis is exerted by transcription factors that control the expression of genes for the various granule proteins. It cannot be ruled out that posttranscriptional control occurs so that biosynthesis of proteins is not a precise reflection of the corresponding mRNA levels. MB, myeloblast; PMC, promyelocyte; MC, myelocyte; MMC, metamyelocyte; BC, band cell; Segm., segmented cell. Niels Borregaard, and Jack B. Cowland Blood 1997;89:3503-3521 ©1997 by American Society of Hematology