Exacerbation of atopic dermatitis on grass pollen exposure in an environmental challenge chamber Thomas Werfel, MD, Annice Heratizadeh, MD, Margarete.

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Presentation transcript:

Exacerbation of atopic dermatitis on grass pollen exposure in an environmental challenge chamber Thomas Werfel, MD, Annice Heratizadeh, MD, Margarete Niebuhr, MD, Alexander Kapp, MD, Lennart Matthias Roesner, PhD, Annika Karch, MSc, Veit J. Erpenbeck, MD, PhD, Christian Lösche, MD, Thomas Jung, MD, Norbert Krug, MD, Philipp Badorrek, MD, Jens M. Hohlfeld, MD Journal of Allergy and Clinical Immunology Volume 136, Issue 1, Pages 96-103.e9 (July 2015) DOI: 10.1016/j.jaci.2015.04.015 Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Flow chart of the study. Journal of Allergy and Clinical Immunology 2015 136, 96-103.e9DOI: (10.1016/j.jaci.2015.04.015) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Course of objective SCORAD scores. This figure is based on the PP population. In the verum group 1 patient was excluded from further statistical analysis from postchallenge day 2 onward. In the placebo group 1 patient was excluded from day 4. *P < .05 and **P < .01. P values are derived from paired comparisons against the respective prechallenge values (each treatment group separately). The box and whisker diagram illustrates the smallest value, the lower quartile, the median, the upper quartile, and the sample maximum of the data series. Journal of Allergy and Clinical Immunology 2015 136, 96-103.e9DOI: (10.1016/j.jaci.2015.04.015) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Time course of worsening of eczema in air-exposed skin from prechallenge day 1 until postchallenge day 5, as assessed by local SCORAD scores, in the verum and placebo groups (box and whisker diagram). *P < .05 and **P < .01. Journal of Allergy and Clinical Immunology 2015 136, 96-103.e9DOI: (10.1016/j.jaci.2015.04.015) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 4 Photodocumentation before (left panels) and after (right panels) grass pollen challenge of 2 patients of the open-label study phase B. A, Prechallenge day 1 versus postchallenge day 2. B, Screening versus postchallenge day 3. Journal of Allergy and Clinical Immunology 2015 136, 96-103.e9DOI: (10.1016/j.jaci.2015.04.015) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 The increase in objective SCORAD score from prechallenge day 1 (baseline) to postchallenge day 3 was significantly higher in the verum group (P = .010, analysis of covariance). The box and whisker diagram illustrates the smallest value, the lower quartile, the median, the upper quartile, and the sample maximum of the data series. *P < .05. Journal of Allergy and Clinical Immunology 2015 136, 96-103.e9DOI: (10.1016/j.jaci.2015.04.015) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 Difference in objective SCORAD scores from prechallenge day 1 to postchallenge day 5 (box and whisker diagram). The increase in points is significantly higher in the verum group (P = .042, Mann-Whitney rank sum test). *P < .05. Journal of Allergy and Clinical Immunology 2015 136, 96-103.e9DOI: (10.1016/j.jaci.2015.04.015) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions