T Cell Receptor-γ Gene Analysis of CD30+ Large Atypical Individual Cells in CD30+ Large Primary Cutaneous T Cell Lymphomas Sylke Gellrich, Anke Wilks,

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T Cell Receptor-γ Gene Analysis of CD30+ Large Atypical Individual Cells in CD30+ Large Primary Cutaneous T Cell Lymphomas Sylke Gellrich, Anke Wilks, Ansgar Lukowsky, Martin Wernicke, Astrid Müller, J. Marcus Muche, Tanja Fischer, Kim Christian Jasch, Heike Audring, Wolfram Sterry Journal of Investigative Dermatology Volume 120, Issue 4, Pages 670-675 (April 2003) DOI: 10.1046/j.1523-1747.2003.12101.x Copyright © 2003 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Patients with CD30+ large primary cutaneous T cell lymphoma. Patient I, lower leg; patient II, finger; patient III, upper leg, biopsy IIIa; patient IV, hand wrist. (A) Clinical occurrence. (B) Hematoxylin and eosin staining of lesional skin, original magnification×40. (C) Immunohistochemical anti-CD30-staining of lesional skin, original magnification×40. Journal of Investigative Dermatology 2003 120, 670-675DOI: (10.1046/j.1523-1747.2003.12101.x) Copyright © 2003 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 2 FFA-TCR-γ of Patient III. (A) Lesional skin prior to treatment: TCR-γ1. (B) Lesional skin under vaccination therapy: TCR-γ1. (C) Peripheral blood lymphocytes, leukemic stage: TCR-γ1. (D) Lesional skin under vaccination therapy: TCR-γ2. (E) Peripheral blood lymphocytes, leukemic stage: TCR-γ2. Abscissa: sequence length in bp. Vertical axis: fluorescent intensity. Journal of Investigative Dermatology 2003 120, 670-675DOI: (10.1046/j.1523-1747.2003.12101.x) Copyright © 2003 The Society for Investigative Dermatology, Inc Terms and Conditions