Post-bronchodilator forced expiratory volume in 1 s (FEV1) to forced vital capacity (FVC) ratio in subjects aged >50 yrs. Post-bronchodilator forced expiratory volume in 1 s (FEV1) to forced vital capacity (FVC) ratio in subjects aged >50 yrs. Red line corresponds to the fixed 0.7 cut-off, the black line to the age- and sex-specific lower limit of normal (LLN). Red circles represent false positive subjects with the fixed ratio, green ones are true positive according to LLN. Reproduced and modified from [27] with permission from the publisher. A. Bourdin et al. Eur Respir Rev 2009;18:198-212 ©2009 by European Respiratory Society