Title: Biology 2/22/07 Objectives: Class Topics 6/7/2019 Title: Biology 2/22/07 Objectives: To learning about autosomal human genetic disorders and review for the Chapter 8 Quiz 3. Class Topics Hand in Gene Spy W.S. before the bell rings please Correct pedigree lab Autosomal Human Genetic Disorders Quiz review “They (fathers) give it (the Y chromosome) to their sons because if they give it to their daughter, they’re not a daughter.” Nathan Steele Friday, June 07, 2019 10:01 AM

Class Assignments W.S. “X marks the spot” 2/22/07 6/7/2019 Class Assignments What By When W.S. “X marks the spot” 2/22/07 Chapter 8 Quiz 3 2/26/07 Due this class period Due next class period Due in the future

6/7/2019 Grade Sheet 2A – p. 157 (5 pts.)

6/7/2019 From: http://campus.queens.edu/faculty/jannr/Genetics/images/height.jpg

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Traits influenced by environment 6/7/2019 Traits influenced by environment Hydrangea Color is influenced by the soil pH Acidic = blue flowers Neutral, basic – pink/red flowers Skin color Tanning Traits determined by nutrition Studied by scientists using identical twins

Twins 2 eggs + 2 sperm - fraternal 1 egg + 1 sperm - identical 6/7/2019 2 eggs + 2 sperm - fraternal siblings - no closer genetically 1 egg + 1 sperm - identical same exact genome used in genetic studies conjoined or Siamese twins aren’t separated Twins

Calico cat: State cat of Maryland! 6/7/2019 Calico cat: State cat of Maryland! From: http://www.thecalico.com/pictures/Pumpkin3.jpg http://www.msa.md.gov/msa/mdmanual/01glance/symbols/html/cat.html

6/7/2019 Links Sex-linked Inheritance quiz Blue People of Kentucky

Autosomal Human Genetic Disorders 6/7/2019 Cystic Fibrosis Recessive mostly European ancestory Thick mucus clogs breathing passages Sickle-Cell Anemia Mostly African or Mediterranean ancestory Heterozygous immune to malaria Causes RBC to be sickle shaped Autosomal Human Genetic Disorders

Autosomal Human Genetic Disorders 6/7/2019 Olney’s albino squirrels Albinism Recessive Can’t produce melanin Tay-Sachs Mostly Eastern European Jews Nervous system breaks down (death before age 5 Autosomal Human Genetic Disorders

Autosomal Human Genetic Disorders 6/7/2019 Phenylketonuria (PKU) Recessive Can’t live without special diet Huntington’s Disease Dominant Muscular and nervous systems break down in late 30’s early 40’s (dead in 10-15 years) Autosomal Human Genetic Disorders

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Chapter 8 Quiz 3 Pedigree X-linked crosses 6/7/2019 Chapter 8 Quiz 3 Pedigree Read and draw Know why they are recessive or dominant and sex-linked or autosomal X-linked crosses Just like on board Inheritance of sex-linked chromosomes Examples of multiple alleles and polygenic traits Human genetic diseases (matching)

Gene Therapy Replacing defective gene Cystic fibrosis 6/7/2019 Gene Therapy Replacing defective gene Cystic fibrosis Incorporated into virus Inject DNA into cell Stem cell research What’s a stem cell? How would this help?

Review Magazine article “Go ahead and kiss your cousin” 6/7/2019 Review Magazine article “Go ahead and kiss your cousin” Why are neural degenerative diseases 8 times more common in Bradford than the rest of the UK? (62) What are lethal alleles (62)? Why is it likely that 80% of marriages in history were between 2nd cousins or closer? (62) Why would some rich families encourage cousin marriages? (63) Why do some cases of inbreeding lead to many diseases while others do not? (63) What is outbreeding? (64) What are some problems with outbreeding? (64)

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