Antibiofilm effects of zinc pyrithione and silver sulfadiazine individually and in combination against S. aureus, A. baumannii, and P. aeruginosa. Antibiofilm.

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Antibiofilm effects of zinc pyrithione and silver sulfadiazine individually and in combination against S. aureus, A. baumannii, and P. aeruginosa. Antibiofilm effects of zinc pyrithione and silver sulfadiazine individually and in combination against S. aureus, A. baumannii, and P. aeruginosa. The log decrease in the number of biofilm-associated cells following treatment with 2-fold-increasing concentrations (0 to 128 µg·ml−1) of silver sulfadiazine (gray bars), zinc pyrithione (black bars), or silver sulfadiazine-zinc pyrithione combination (white bars) in comparison to mock-treated (DMSO) biofilms for S. aureus (A), A. baumannii (B), and P. aeruginosa (C). Error bars represent standard deviations. Significant differences between the results seen with silver sulfadiazine and silver sulfadiazine-zinc pyrithione are indicated. *, P ≤ 0.05; **, P ≤ 0.01 (Student’s t test). Catlyn Blanchard et al. mSphere 2016; doi:10.1128/mSphere.00194-16