Chronic effect of 28-day oral administration of vehicle (n = 6–10/group) or aprocitentan 1, 10, and 100 mg/kg per day (n = 6–9/group) on mean arterial.

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Presentation transcript:

Chronic effect of 28-day oral administration of vehicle (n = 6–10/group) or aprocitentan 1, 10, and 100 mg/kg per day (n = 6–9/group) on mean arterial pressure (A), heart rate (B), renal vascular resistance (C), left ventricle plus septum/heart weight ratio (D), and N-terminal pro b-type natriuretic peptide (NT-proBNP) plasma concentrations (E) in DOCA-salt rats. Chronic effect of 28-day oral administration of vehicle (n = 6–10/group) or aprocitentan 1, 10, and 100 mg/kg per day (n = 6–9/group) on mean arterial pressure (A), heart rate (B), renal vascular resistance (C), left ventricle plus septum/heart weight ratio (D), and N-terminal pro b-type natriuretic peptide (NT-proBNP) plasma concentrations (E) in DOCA-salt rats. Wistar rats (n = 6/group) served as control. Data are presented as mean ± S.E.M.; “w” denotes week after DOCA-salt treatment initiation; *P < 0.05 compared with vehicle-treated DOCA-salt rats. Frederic Trensz et al. J Pharmacol Exp Ther 2019;368:462-473 Copyright © 2019 The Author(s).