Within-group comparisons of adjusted mean±SEM of absolute change in peak systolic strain (%) from baseline to 12 months using the American Heart Association 16-segment model of the left ventricle. Within-group comparisons of adjusted mean±SEM of absolute change in peak systolic strain (%) from baseline to 12 months using the American Heart Association 16-segment model of the left ventricle. Strain values are conventionally expressed on a negative scale as a percentage change in length from baseline, with larger changes denoting better function. P values are for the interaction of treatment group with time in a linear mixed-effects model. *P<0.05; **P<0.01. AHA, American Heart Association. Aghogho Odudu et al. CJASN 2015;10:1408-1417 ©2015 by American Society of Nephrology