Evaluating Success of Current Treatments for HCM

Hypertrophic Cardiomyopathy (HCM)

HCM Prevalence

Diagnosis Process

Identifying HCM

Nonspecific Symptoms of HCM

MOGE(S) Classification of Cardiomyopathies

Heterogeneous HCM -- A Broad Term

Diagnostic Challenges

Case Presentation

Case Presentation (cont)

Case Presentation (cont)

Case Presentation (cont)

Disease Pathway

Obstruction Is Associated With Symptom Progression in HCM

Treatment Algorithm for Obstructive HCM

Case Presentation (cont) Treatment Approach

No HCM-Specific Treatments to Date

Nonobstructive HCM

More Options for Obstructive HCM Invasive Septal Reduction Therapy

Investigational Therapies

Mavacamten (MYK-461)

PIONEER-HCM (Phase 2 Study) Mavacamten Reduces LVOT Gradients

PIONEER-HCM (Phase 2 Study) Improvement in Symptoms and Functional Capacity

Ongoing Trials in Obstructive HCM and NOHCM

PIONEER-OLE Positive Six-Month Safety and Efficacy Data

Conclusion

Abbreviations

Abbreviations (cont)