Expression of smooth muscle and extracellular matrix proteins in relation to airway function in asthma Annelies M. Slats, MD, Kirsten Janssen, BHe, Annemarie.

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Expression of smooth muscle and extracellular matrix proteins in relation to airway function in asthma Annelies M. Slats, MD, Kirsten Janssen, BHe, Annemarie van Schadewijk, MSc, Dirk T. van der Plas, BSc, Robert Schot, BSc, Joost G. van den Aardweg, MD, PhD, Johan C. de Jongste, MD, PhD, Pieter S. Hiemstra, PhD, Thais Mauad, MD, Klaus F. Rabe, MD, PhD, Peter J. Sterk, MD, PhD Journal of Allergy and Clinical Immunology Volume 121, Issue 5, Pages 1196-1202 (May 2008) DOI: 10.1016/j.jaci.2008.02.017 Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Examples of the immunohistochemical stainings. The same biopsy section is shown for the immunohistochemical staining for α-SM-actin (A), myosin (B), desmin (C), vimentin (D), calponin (E), MLCK (F), type III collagen (G), fibronectin (H), and elastin (I). Original magnification ×200 for all graphs. Journal of Allergy and Clinical Immunology 2008 121, 1196-1202DOI: (10.1016/j.jaci.2008.02.017) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Associations between smooth muscle markers and lung function parameters. The mean density of desmin (r = 0.61; P = .02) (A) and MLCK (r = 0.55; P = .05) (B) in relationship with FEV1% of predicted; desmin (r = −0.56; P = .04) (C) and actin (r = −0.62; P = .02) (D) in relationship with PC20 methacholine; and desmin (r = −0.60; P = .03) (E) and MLCK (r = −0.60; P = .03) (F) in relationship with the change in RrsInsp by deep breath. DI, Deep inspiration; SM, smooth muscle. Journal of Allergy and Clinical Immunology 2008 121, 1196-1202DOI: (10.1016/j.jaci.2008.02.017) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions