Surgical Ventricular Restoration for Patients With Ischemic Heart Failure: Determinants of Two-Year Survival Tomasz G. Witkowski, MD, Ellen A. ten Brinke,

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Surgical Ventricular Restoration for Patients With Ischemic Heart Failure: Determinants of Two-Year Survival Tomasz G. Witkowski, MD, Ellen A. ten Brinke, MD, Victoria Delgado, MD, Arnold C.T. Ng, MBBS, Matteo Bertini, MD, Nina Ajmone Marsan, MD, See H. Ewe, MBBS, Dominique Auger, MD, Kelvin H. Yiu, MBBS, Jerry Braun, MD, Patrick Klein, MD, Paul Steendijk, MD, PhD, Michel I.M. Versteegh, MD, Robert J. Klautz, MD, PhD, Jeroen J. Bax, MD, PhD The Annals of Thoracic Surgery Volume 91, Issue 2, Pages 491-498 (February 2011) DOI: 10.1016/j.athoracsur.2010.09.074 Copyright © 2011 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Change in New York Heart Association (NYHA) functional class in patients with heart failure after surgical ventricular restoration. The Annals of Thoracic Surgery 2011 91, 491-498DOI: (10.1016/j.athoracsur.2010.09.074) Copyright © 2011 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Changes in distance covered in 6-minute walk test (A) and quality of life (B) at 6 months after surgical ventricular restoration. (IQR = interquartile range.) The Annals of Thoracic Surgery 2011 91, 491-498DOI: (10.1016/j.athoracsur.2010.09.074) Copyright © 2011 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 Changes in echocardiographic variables at 6 months after surgical ventricular restoration. (A) Changes in left ventricular end-diastolic volume index (LVEDVI). (B) Changes in left ventricular end-systolic volume index (LVESVI). (C) Changes in left ventricular (LV) ejection fraction. (D) Changes in left ventricular mass index. (IQR = interquartile range.) The Annals of Thoracic Surgery 2011 91, 491-498DOI: (10.1016/j.athoracsur.2010.09.074) Copyright © 2011 The Society of Thoracic Surgeons Terms and Conditions

Fig 4 Cox cumulative hazard function in patients with residual postsurgical ventricular restoration left ventricular end-systolic volume index (LVESVI) of at least 60 mL/m2 (solid line)or less than 60 mL/m2 (dotted line). (CI = confidence interval; HF = heart failure; HR = hazard ratio.) The Annals of Thoracic Surgery 2011 91, 491-498DOI: (10.1016/j.athoracsur.2010.09.074) Copyright © 2011 The Society of Thoracic Surgeons Terms and Conditions

Fig 5 Kaplan-Meier curves with the cumulative survival rate for the composite end point (death and hospitalization owing to heart failure) in patients (pts) with ischemic heart failure with residual postsurgical left ventricular end-systolic volume index (LVESVI) of at least 60 mL/m2 (solid line) or less than 60 mL/m2 (dashed line). The Annals of Thoracic Surgery 2011 91, 491-498DOI: (10.1016/j.athoracsur.2010.09.074) Copyright © 2011 The Society of Thoracic Surgeons Terms and Conditions