Effects of hyaluronic acid (HA) viscosupplementation on peripheral Th cells in knee and hip osteoarthritis A. Lùrati, A. Laria, D. Mazzocchi, K.A. Re,

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Effects of hyaluronic acid (HA) viscosupplementation on peripheral Th cells in knee and hip osteoarthritis A. Lùrati, A. Laria, D. Mazzocchi, K.A. Re, M. Marrazza, M. Scarpellini Osteoarthritis and Cartilage Volume 23, Issue 1, Pages 88-93 (January 2015) DOI: 10.1016/j.joca.2014.09.010 Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Global Th CD4+ levels observed in each subject in the five groups at baseline (*P = 0.01 between mean values of control group and other OA groups). Osteoarthritis and Cartilage 2015 23, 88-93DOI: (10.1016/j.joca.2014.09.010) Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Activated Th cells CD4+CD38+ (continuous line) and CD4+DR+ (dotted line) levels in the five groups at baseline (*P = 0.01 between the CD4+CD38+ levels of control group and OA groups; **P = 0.04 between the CD4+DR+ levels of control group and OA groups). Log10 scale used. Osteoarthritis and Cartilage 2015 23, 88-93DOI: (10.1016/j.joca.2014.09.010) Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 Variation of Activated Th Cells CD4+CD38+ (black line) and CD4+DR+ (grey line) after the course of HA. Cumulative data of groups B1 and B2. Log 10 scale used (*P = 0.01 between the CD4+CD38+ levels; **P = 0.03 between the CD4+DR+ levels). Osteoarthritis and Cartilage 2015 23, 88-93DOI: (10.1016/j.joca.2014.09.010) Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions

Fig. 4 a and b: Relationship between Lequesne functional pain value and activated Th cells value at baseline and 3-months (linear regression model with observed Lequesne pain value in Y axis and predicted adjusted value in X axis). Eta squared value between activated Th cells and Lequesne index of 15.6 ± 2.3 and 11.5 ± 1.6 at baseline and at 3 months, respectively (P = 0.02). Osteoarthritis and Cartilage 2015 23, 88-93DOI: (10.1016/j.joca.2014.09.010) Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions