Radiographic osteoarthritis at three joint sites and FRZB, LRP5, and LRP6 polymorphisms in two population-based cohorts J.M. Kerkhof, M.Sc., A.G. Uitterlinden,

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Radiographic osteoarthritis at three joint sites and FRZB, LRP5, and LRP6 polymorphisms in two population-based cohorts J.M. Kerkhof, M.Sc., A.G. Uitterlinden, Ph.D., A.M. Valdes, Ph.D., D.J. Hart, Ph.D., F. Rivadeneira, M.D., Ph.D., M. Jhamai, B.Sc., A. Hofman, M.D., Ph.D., H.A.P. Pols, M.D., Ph.D., S.M.A. Bierma-Zeinstra, Ph.D., T.D. Spector, M.D., J.B. van Meurs, Ph.D. Osteoarthritis and Cartilage Volume 16, Issue 10, Pages 1141-1149 (October 2008) DOI: 10.1016/j.joca.2008.02.007 Copyright © 2008 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 CTX-II levels by FRZB Arg324Gly genotype of males and females of the Rotterdam Study and of females of the Chingford Study. Values are adjusted for age and BMI. Osteoarthritis and Cartilage 2008 16, 1141-1149DOI: (10.1016/j.joca.2008.02.007) Copyright © 2008 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Forest plot of studies regarding the FRZB Arg324Gly polymorphism. (A) Forest plot of studies regarding FRZB Arg324Gly polymorphism and hip OA. (B) Forest plot of studies regarding FRZB Arg324Gly polymorphism and knee OA. Osteoarthritis and Cartilage 2008 16, 1141-1149DOI: (10.1016/j.joca.2008.02.007) Copyright © 2008 Osteoarthritis Research Society International Terms and Conditions