Representative photomicrographs of immunohistochemical staining for Wilms’ tumor 1 (WT1) and cleaved caspase-3 in mouse kidney sections at 10, 20, and.

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Representative photomicrographs of immunohistochemical staining for Wilms’ tumor 1 (WT1) and cleaved caspase-3 in mouse kidney sections at 10, 20, and 25 wk after injection with 225Ac-labeled antibody. Representative photomicrographs of immunohistochemical staining for Wilms’ tumor 1 (WT1) and cleaved caspase-3 in mouse kidney sections at 10, 20, and 25 wk after injection with 225Ac-labeled antibody. (A, B, and C) Ten, 20, and 25 wk, respectively: No significant decrease in the number of WT1-positive cells per glomerulus from 10 to 25 wk. Increase in the number of caspase-3–positive cells (arrows) at 20 and 25 wk (E and F, respectively) as compared with 10 wk (D) after injection. Jaspreet Singh Jaggi et al. JASN 2005;16:2677-2689 ©2005 by American Society of Nephrology