Volume 57, Issue 5, Pages (May 2000)

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Volume 57, Issue 5, Pages 1927-1935 (May 2000) Estrogen worsens incipient hypertriglyceridemic glomerular injury in the obese Zucker rat Frazier T. Stevenson, Carrie M. Wheeldon, Matthew D. Gades, George A. Kaysen, Judith S. Stern, Harry Van Goor Kidney International Volume 57, Issue 5, Pages 1927-1935 (May 2000) DOI: 10.1046/j.1523-1755.2000.00042.x Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 1 Urinary albumin excretion in seven-week obese Zucker rats (OZRs). Abbreviations are: sham, sham operated; Ovx, ovariectomized; Ovx + E, ovariectomized with estrogen replacement (N = 20 to 30 per group). Kidney International 2000 57, 1927-1935DOI: (10.1046/j.1523-1755.2000.00042.x) Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 2 Total and very low density lipoprotein (VLDL) lipids in seven-week OZRs (N = 20 to 30 per group). Symbols are: (▪) sham; (□) Ovx; (▪) Ovx + E; *P < 0.05 vs. sham;+P < 0.05 vs. Ovx. Definitions are in the legend toFigure 1. Kidney International 2000 57, 1927-1935DOI: (10.1046/j.1523-1755.2000.00042.x) Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 3 Linear regression of VLDL triglycerides (TG) versus log (urinary albumin excretion, UAE) in seven-week OZRs (r2 = 0.604,P < 0.0001). Kidney International 2000 57, 1927-1935DOI: (10.1046/j.1523-1755.2000.00042.x) Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 4 Apolipoprotein scoring in seven-week OZRs. Scoring represents mean of 30 to 50 glomeruli per rat with five to six per group. Symbols are: (▪) sham; (□) Ovx; (▪) Ovx + E; *P < 0.05 vs. sham;+P < 0.05 vs. Ovx. Abbreviation ND is not detected. Kidney International 2000 57, 1927-1935DOI: (10.1046/j.1523-1755.2000.00042.x) Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 5 Representative glomerular apolipoprotein immunohistochemistry in seven-week OZRs. Sections represent staining in estrogen-supplemented (a, c, ande) and sham-operated (b, d, andf) rats. Specific antibodies against apo A-I (a and b), apo A-IV (c and d), and apo B (e and f) were used. The arrow denotes tubular apo A-IV staining (magnification ×40). Kidney International 2000 57, 1927-1935DOI: (10.1046/j.1523-1755.2000.00042.x) Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 6 Glomerular gene expression in seven-week OZRs by RT-PCR. The results were determined in duplicate (N = 4 in each group). Kidney International 2000 57, 1927-1935DOI: (10.1046/j.1523-1755.2000.00042.x) Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 7 Glomerular (A) and interstitial (B) monocyte/macrophage deposition by ED1 staining. Means represent 20 scores from four to five rats per group. Symbols are: (▪) sham; (□) Ovx; (▪) Ovx + E; *P < 0.05 vs. Ovx. Kidney International 2000 57, 1927-1935DOI: (10.1046/j.1523-1755.2000.00042.x) Copyright © 2000 International Society of Nephrology Terms and Conditions