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Overview of Cytochrome P450 Enzymes: The Role of Polymorphisms Simon Kung, M.D. Associate Professor of Psychiatry Mayo Clinic

Liver Cytochrome P450 Enzymes Zanger, U. M., & Schwab, M. (2013). Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation. Pharmacology & therapeutics, 138(1), 103-141.

P450 Enzyme Polymorphisms 2D6 > 100 2C19 > 30 1A2 > 20 http://www.cypalleles.ki.se/

Factors Affecting Cytochrome P450 Enzymes Gender Age Disease Factors Affecting Cytochrome P450 Enzymes Diurnal influences Hormones Zanger, U. M., & Schwab, M. (2013). Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation. Pharmacology & therapeutics, 138(1), 103-141.

The Cytochrome 2D6 Enzyme One nucleotide change could significantly affect enzyme performance Zanger, U. M., & Schwab, M. (2013). Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation. Pharmacology & therapeutics, 138(1), 103-141.

Factors Affecting CYP 450 Enzymes CYP2C19 (6.8%) · Polymorphism · Induction · Inflammation · Gender ( ) ( ) ( ) CYP2D6 (20%) · Polymorphism · Inflammation ( ) ( ) Zanger, U. M., & Schwab, M. (2013). Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation. Pharmacology & therapeutics, 138(1), 103-141.

Key Points The cytochrome P450 enzyme system metabolizes many of our oral medications. Many of these enzymes have polymorphisms. The enzyme activity is affected by nongenetic factors, such as gender, age, and inflammation.

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