Vascular remodeling is a feature of asthma and nonasthmatic eosinophilic bronchitis Salman Siddiqui, MRCP, Amanda Sutcliffe, BSc (Hons), Aarti Shikotra,

Slides:

Advertisements

Similar presentations

Joint modeling of parentally reported and physician-confirmed wheeze identifies children with persistent troublesome wheezing Danielle C.M. Belgrave, MSc,

Advertisements

A bioinformatics approach to identify patients with symptomatic peanut allergy using peptide microarray immunoassay Jing Lin, PhD, Francesca M. Bruni,

Control of immunopathology during chikungunya virus infection Caroline Petitdemange, PhD, Nadia Wauquier, PhD, Vincent Vieillard, PhD Journal of Allergy.

Characteristics of childhood peanut allergy in the Australian Capital Territory, 1995 to 2007 Raymond James Mullins, MBBS, PhD, FRACP, FRCPA, Keith B.G.

Severe adult-onset asthma: A distinct phenotype

Incidence of parentally reported and clinically diagnosed food hypersensitivity in the first year of life Carina Venter, BSc, Brett Pereira, MRCP, Jane.

D-dimer: A biomarker for antihistamine-resistant chronic urticaria

Peter Vadas, MD, PhD, Boris Perelman, PhD, Gary Liss, MD, MS

Alveolar nitric oxide and asthma control in mild untreated asthma

Simultaneously increased fraction of exhaled nitric oxide levels and blood eosinophil counts relate to increased asthma morbidity Andrei Malinovschi,

Anne M. Fitzpatrick, PhD, MSCR, W. Gerald Teague, MD

Incidence of parentally reported and clinically diagnosed food hypersensitivity in the first year of life Carina Venter, BSc, Brett Pereira, MRCP, Jane.

Fibrocyte localization to the airway smooth muscle is a feature of asthma Ruth Saunders, PhD, Salman Siddiqui, MRCP, Davinder Kaur, PhD, Camille Doe,

Obstructive sleep apnea syndrome and inflammation

Effect of IVL745, a VLA-4 antagonist, on allergen-induced bronchoconstriction in patients with asthma Virginia Norris, MRCP, Lee Choong, BSc, Duyen Tran,

Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD

Sputum indoleamine-2, 3-dioxygenase activity is increased in asthmatic airways by using inhaled corticosteroids Kittipong Maneechotesuwan, MD, PhD, Sirinya.

Stephen J. Fowler, MD, Gaël Tavernier, PhD, Robert Niven, MD

Epidemic asthma and the role of the fungal mold Alternaria alternata

David A. Khan, MD Journal of Allergy and Clinical Immunology

Airway remodeling in subjects with severe asthma with or without chronic persistent airflow obstruction Marta Kaminska, MD, Susan Foley, MD, Karim Maghni,

Is 9 more than 2 also in allergic airway inflammation?

Airway inflammation in patients with asthma with high-fixed or low-fixed plus as-needed budesonide/formoterol Ian D. Pavord, DM, FRCP, Peter K. Jeffery,

Asthma therapy and airway remodeling

Lung function decline and variable airway inflammatory pattern: Longitudinal analysis of severe asthma Christopher Newby, PhD, Joshua Agbetile, MRCP,

Eosinophil protein in airway macrophages: A novel biomarker of eosinophilic inflammation in patients with asthma Neeta S. Kulkarni, MD, Fay Hollins,

Lieuwe D. Bos, MSc, PhD, Peter J. Sterk, MD, PhD, Stephen J

Susan C. Foley, MD, David Préfontaine, MSc, Qutayba Hamid, MD, PhD

Pediatric severe asthma is characterized by eosinophilia and remodeling without TH2 cytokines Cara J. Bossley, MBChB, Louise Fleming, MD, Atul Gupta,

Peter M. Wolfgram, MD, David B. Allen, MD

Etiology of asthma exacerbations

Jewlya Lynn, PhD, Sophie Oppenheimer, MS, MPH, Lorena Zimmer, MA

Outcomes after cessation of mepolizumab therapy in severe eosinophilic asthma: A 12- month follow-up analysis Pranabashis Haldar, MD, Christopher E. Brightling,

Time for a paradigm shift in asthma treatment: From relieving bronchospasm to controlling systemic inflammation Leif Bjermer, MD Journal of Allergy.

What are the best outcome measurements for atopic eczema

The role of the mast cell in the pathophysiology of asthma

Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management Scott H. Sicherer, MD, Hugh A. Sampson, MD Journal.

Myeloid and plasmacytoid dendritic cells in induced sputum after allergen inhalation in subjects with asthma Benny Dua, MSc, Richard M. Watson, BSc,

Peter Vadas, MD, PhD, Boris Perelman, PhD, Gary Liss, MD, MS

Claus Bachert, MD, PhD, Cezmi A. Akdis, MD

Lisa G. Wood, PhD, Manohar L. Garg, PhD, Peter G. Gibson, MBBS

What is an “eosinophilic phenotype” of asthma?

H. William Kelly, PharmD Journal of Allergy and Clinical Immunology

Autophagy: Nobel Prize 2016 and allergy and asthma research

Volume 138, Issue 5, Pages (November 2010)

Effectiveness of voriconazole in the treatment of Aspergillus fumigatus–associated asthma (EVITA3 study) Joshua Agbetile, MD, Michelle Bourne, RGN, Abbie.

Mary F. Linehan, PhD, Timothy L. Frank, MD, Michelle L

Prevention of food allergy: Beyond peanut

Correlation between CCL26 production by human bronchial epithelial cells and airway eosinophils: Involvement in patients with severe eosinophilic asthma

Benjamin Chaigne, MD, Hervé Watier, MD, PhD

Eosinophilic esophagitis treated with immunotherapy to dust mites

Chrystalleni Hadjicharalambous, MSc, Gordon Dent, PhD, Richard D

Volume 138, Issue 5, Pages (November 2010)

Biju Thomas, MD, Robert Anthony Hirst, PhD, Mina H

Bronchoalveolar lavage invariant natural killer T cells are not increased in asthma Kugathasan Mutalithas, MRCP, Joanne Croudace, PhD, Cristina Guillen,

Macrolide antibiotics and asthma treatment

Nitrosative stress in the bronchial mucosa of severe chronic obstructive pulmonary disease Fabio L.M. Ricciardolo, MD, Gaetano Caramori, MD, PhD, Kazuhiro.

Asthma: The past, future, environment, and costs

Dendritic cells in nasal mucosa of subjects with different allergic sensitizations Susanne M. Reinartz, MD, Joost van Tongeren, MD, Danielle van Egmond,

Environmental factors and eosinophilic esophagitis

The GILL study: Glycerin-induced local reactions in immunotherapy

Systemic responses after bronchial aspirin challenge in sensitive patients with asthma Joanna S. Makowska, MD, PhD, Janina Grzegorczyk, PhD, Barbara Bienkiewicz,

Confirmation and improvement of criteria for clinical phenotyping in common variable immunodeficiency disorders in replicate cohorts Helen Chapel, MA,

Natural history of cow’s milk allergy

Differences in airway remodeling between subjects with severe and moderate asthma Carmela Pepe, MD, Susan Foley, MD, Joanne Shannon, MD, Catherine Lemiere,

The influence of asthma control on the severity of virus-induced asthma exacerbations David J. Jackson, MRCP, PhD, Maria-Belen Trujillo-Torralbo, BSc,

Progression of asthma in childhood

Sputum indoleamine-2, 3-dioxygenase activity is increased in asthmatic airways by using inhaled corticosteroids Kittipong Maneechotesuwan, MD, PhD, Sirinya.

Primary prevention of asthma and allergy

Aarti Shikotra, BSc, David F. Choy, BSc, Chandra M

Presentation transcript:

Vascular remodeling is a feature of asthma and nonasthmatic eosinophilic bronchitis Salman Siddiqui, MRCP, Amanda Sutcliffe, BSc (Hons), Aarti Shikotra, BSc (Hons), Lucy Woodman, BSc (Hons), Camille Doe, BSc (Hons), MSc, Sue McKenna, RGN, Andrew Wardlaw, FRCP, PhD, Peter Bradding, DM, FRCP, Ian Pavord, DM, FRCP, Christopher Brightling, PhD, MRCP Journal of Allergy and Clinical Immunology Volume 120, Issue 4, Pages 813-819 (October 2007) DOI: 10.1016/j.jaci.2007.05.028 Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Immunohistochemistry vascular remodeling. Representative photomicrographs (×200) show bronchial biopsy sections stained with monoclonal antibody against PECAM-1/EN4. A, Control subject: relatively few vessels. B, Patient with mild intermittent asthma (GINA 1): increased vascularity. C, Subject with EB: multiple vessels in the subepithelium. D, Subject with refractory asthma: multiple vessels surrounding submucosal glands. RBM thickening is evident in subjects with asthma and EB. Journal of Allergy and Clinical Immunology 2007 120, 813-819DOI: (10.1016/j.jaci.2007.05.028) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 MMCs, cohort 1: control group; GINA 1-2 (intermittent to mild persistent asthma); GINA 3-5 (moderate to severe persistent asthma), including refractory asthma alone and nonrefractory; EB. Journal of Allergy and Clinical Immunology 2007 120, 813-819DOI: (10.1016/j.jaci.2007.05.028) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Induced sputum supernatant VEGF (pg/g), cohort 2. Sputum VEGF concentration in the control group; GINA 1-2 (intermittent to mild persistent asthma); GINA 3-5 (moderate to severe persistent asthma) including refractory asthma alone and nonrefractory; EB. Journal of Allergy and Clinical Immunology 2007 120, 813-819DOI: (10.1016/j.jaci.2007.05.028) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 4 Vascular remodeling and airflow obstruction. In the subjects with asthma, there was an inverse association between the postbronchodilator FEV1 % predicted and the MCCs in cohort 1 (A) and sputum VEGF concentration in cohort 2 (B). Journal of Allergy and Clinical Immunology 2007 120, 813-819DOI: (10.1016/j.jaci.2007.05.028) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions