DMT1 expression in the mesencephalon of MPTP-intoxicated mice.

Slides:

Advertisements

Similar presentations

Functional Rescue of Dopaminergic Neuron Loss in Parkinson's Disease Mice After Transplantation of Hematopoietic Stem and Progenitor Cells Wassim Altarche-Xifro,

Advertisements

Chronic stress accelerated DSS-induced colitis.

S55746 synergizes with panobinostat in vitro and in vivo in DLBCL

FAM49B controls T cell activation by regulating cytoskeleton remodeling. FAM49B controls T cell activation by regulating cytoskeleton remodeling. (A) J.FAM49B.

Decreased cell polarity and adhesion protein expression after 56Fe radiation. Decreased cell polarity and adhesion protein expression after 56Fe radiation.

H&E staining reveals defects in the CNS of Gpr124−/− mice.

Activation of PKC signaling reverses cell chirality in the myocardium before cardiac looping. Activation of PKC signaling reverses cell chirality in the.

Detection of CD38+IgG1+ memory B cells adjacent to contracted GCs

Klotho reduction increases the expression of cytokine response factors in the CP. (A–C) ICAM1 (A and B) and IRF7 (C) immunoreactivity in the CP of 19-

Confocal laser microscope images of Reelin mRNA detected by in situ hybridization using a biotinylated oligoprobe (base pairs 1264–1311) visualized with.

Impaired lymphatic valve protrusion in Tie2Cre;Piezo1cKO mice.

Klotho reduction in CP primes hippocampal microglia for activation.

The Lbx1FS mutation causes central hypoventilation and loss of CO2 sensitivity in mice. The Lbx1FS mutation causes central hypoventilation and loss of.

Long-term up-regulation of proliferative markers and down-regulation of cell migration factors along with increased intestinal metaplasia after 56Fe radiation.

Effect of α2δ-1 ablation on distribution of CaV2

Klotho depletion increases MHC class II expression in the CP

Klotho reduction causes macrophage invasion into the CP

TUM622 is capable of forming acinar-like structures in 3D ECM

Themis interacts with Shp2 when Shp1 is genetically deleted.

Phosphatase activity associated with Themis is due to its association with Shp1. Phosphatase activity associated with Themis is due to its association.

Fig. 2 Activity-dependent dynamics of β-actin mRNP in neurons from MCP×MBS mouse.(A and B) Examples of β-actin mRNP merge (A) and split (B) events. Activity-dependent.

K107R induces gene expression in an adipocyte-autonomous manner.

Chd5 deficiency in NSCs leads to premature activation.

Analysis of brain and spinal cord of treated Gaa−/− mice and controls

Stat3 promotes lung fibrosis and collagen synthesis independent of Smad3.A.Masson's trichrome stained sections of lung from gp130wt (wt), Smad3−/− (Smad3−/−),

Smaller T cell zone FRC areas in aged spleens.

Mitofilin is localized in individual clusters in the mitochondria of primary adult human fibroblasts. Mitofilin is localized in individual clusters in.

Nuclear Arp3 mediates formation of TCR-induced nuclear actin filaments

Expression of NCoR1∆ID in PAX8−/− mice does not reverse repression of T3-positive target genes. qPCR on the indicated pituitary (A) and neuronal (B) genes.

IL-21 is involved in the pathogenesis of EAM

IL-27–eGFP is highly expressed by cDC1 cells and Ly6Chi monocytes after vaccine adjuvant administration. IL-27–eGFP is highly expressed by cDC1 cells and.

Detection and tracking of individual SNAP-tagged proteins on the surface of living cells. Detection and tracking of individual SNAP-tagged proteins on.

Regulatory CD4+ T cell–derived IL-10 is important for B cell differentiation and the GC response. Regulatory CD4+ T cell–derived IL-10 is important for.

Fig. 4. Loss of DLK expression is neuroprotective in the SOD1G93A mouse model of ALS. Loss of DLK expression is neuroprotective in the SOD1G93A mouse model.

Axonal swelling and impairment of dendritic development in Purkinje cells from Pex14ΔC/ΔC BL/ICR mouse upon treatment with BDNF. Axonal swelling and impairment.

Fig. 5. Nutlin-3 treatment rescues the proliferation and differentiation of NPCs in vitro. Nutlin-3 treatment rescues the proliferation and differentiation.

Development and characterization of hiPSC‐derived neurons from controls and PKAN patients Development and characterization of hiPSC‐derived neurons from.

Impaired TrkB signaling in the cerebellum of Pex14ΔC/ΔC BL/ICR mice.

Cytosolic entry of Lm required for CD8α+ DC recruitment.

Microglial P2X4R modulates oligodendrocyte differentiation

Neuronal ATM level is reduced in mouse models of AD

Fig. 6 Combination therapy with LVSOD2 and LVshCTGF preserves flap volume and reduces fibrosis after RT. Combination therapy with LVSOD2 and LVshCTGF preserves.

P2X4R blockade increases pro‐inflammatory gene expression after EAE

Differential secretion profiles of C. elegans TTR models.

Fig. 8. CCA and ChQ treatment induce accumulation of F-actin rings.

KGF enhances AECII proliferation and susceptibility to IAV infection, ex vivo. KGF enhances AECII proliferation and susceptibility to IAV infection, ex.

Rapamycin inhibits KGF-induced mortality, proliferation, cytokine expression, and susceptibility to IAV infection, in vivo. Rapamycin inhibits KGF-induced.

FGF/ERK inhibition accelerates neural fate conversion of EpiSCs.

NCMs regulate T cell survival in TLOs via PD-L1.

PD-L1 selectively marks circulating NCMs.

Fig. 2. Ex vivo inducible knockout of PDCD2 in ESCs results in loss of S phase entry and increased p53.(A) Growth curve of inducible knockout and WT ESCs.

Figure 4 DNM1 mutations affect protein levels and self-dimerization (A) HeLa cells were transfected with green fluorescent protein (GFP)-tagged mutant.

Chd5 deficiency leads to compromised expression of the repressive histone mark H3K27me3 and up-regulation of ribosomal protein genes. Chd5 deficiency leads.

High-affinity mutants of β3 integrin fail to stimulate RhoA activity and fibronectin fibrillogenesis. High-affinity mutants of β3 integrin fail to stimulate.

USP2a regulates MYC expression through the MDM2–p53 axis.

Fig. 3. Enhanced EGFR signaling in Rhbdf2P159L/P159L mice.

Adult conditional gene deletion of PGC-1α.

Altered luminal pH of the Golgi apparatus in GPHR deficient primary cultured neurons. Altered luminal pH of the Golgi apparatus in GPHR deficient primary.

Chd5-deficient NSCs generate excessive astrocytes at the expense of neurons. Chd5-deficient NSCs generate excessive astrocytes at the expense of neurons.

Sildenafil protects the intestinal epithelium from DSS-induced damage.

PEDF inhibits Wnt/T-cell factor/β-catenin signaling in resting and wounded skin. PEDF inhibits Wnt/T-cell factor/β-catenin signaling in resting and wounded.

Histone crotonylation in kidney tubular cells.

SiRNA directed at Ngn1 inhibited differentiation of inner ear stem cells to β-III tubulin-positive cells. a, Inner ear stem cells treated with siRNA to.

Gene deletion of PGC-1α leads to the loss of dopamine neurons in the SNpc. Gene deletion of PGC-1α leads to the loss of dopamine neurons in the SNpc. A,

GFP is expressed selectively in NPY neurons.

TRAF6 exacerbates I/R-induced neuronal death.

Effects of the genotypes of Rapgef2 and Rapgef6 on the distribution of neural progenitor cells. Effects of the genotypes of Rapgef2 and Rapgef6 on the.

Optogenetic analysis of mPFC neurons.

Fig. 3. LPS induces degeneration of DA neurons and microglial activation in the SN in vivo. LPS (5 µg/3 µl) was unilaterally injected into the SN in the.

Effect of dexamethasone on PCDGF/GP88 mRNA and protein expressions and effect of PCDGF/GP88 on dexamethasone-induced cell death. Effect of dexamethasone.

Presentation transcript:

DMT1 expression in the mesencephalon of MPTP-intoxicated mice. DMT1 expression in the mesencephalon of MPTP-intoxicated mice. (A) Western blot analysis of DMT1 C-terminal isoforms and actin expression in ventral mesencephalon homogenates of control and MPTP-treated mice (n = 4 or 5 per day). (B) Time course of DMT1 +IRE and DMT1 −IRE expression changes (by immunoblot quantification; Top and Middle) and percentage of dopaminergic cell loss (by stereological cell counting of TH-positive DNs; Bottom) after acute MPTP intoxication. **, P < 0.01 compared with control; ##, P < 0.05 compared with day 1. (C and D) Localization of DMT1 isoforms and cell type-specific markers in the coronal mesencephalic sections of control and MPTP-treated mice. (C, Top) Modest DMT1 +IRE expression in the SNpc of control mice. (C, Middle and Bottom) DMT1 +IRE expression (red) in TH-positive dopaminergic neurons (green) and CD11b+ activated microglia (cyan) 2 days after MPTP intoxication. (D, Upper) DMT1 −IRE expression (red) in TH-positive dopaminergic neurons (green) in the SNpc of control mice. (D, Lower) DMT1 −IRE expression (red) in TH-positive dopaminergic neurons (green) in SNpc 2 days after MPTP intoxication. (Scale bar and inset width: 100 μm.)‏ Julio Salazar et al. PNAS 2008;105:47:18578-18583 ©2008 by National Academy of Sciences