Disruption of integrin α8 signalling inhibits Fn1‐mediated metalloproteinase activation and augments the rate of prion replication ASchematic representation.

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Disruption of integrin α8 signalling inhibits Fn1‐mediated metalloproteinase activation and augments the rate of prion replication ASchematic representation of RGD effect. Disruption of integrin α8 signalling inhibits Fn1‐mediated metalloproteinase activation and augments the rate of prion replication ASchematic representation of RGD effect. BIncubation of R7 cells with RGD peptide inhibits secretion of activated MMP2/9 as shown by gelatine zymography. CPreincubation with RGD of R7, but not S7 cells significantly increases the number of PrPSc‐positive cells after prion infection. D, ETransient gene silencing of MMP2 and MMP9 using siRNA significantly increases the number of PrPSc‐positive cells in R7 (D), but not in S7 (E) cells. Masue M Marbiah et al. EMBO J. 2014;33:1527-1547 © as stated in the article, figure or figure legend