Genetic susceptibility to food allergy is linked to differential TH2-TH1 responses in C3H/HeJ and BALB/c mice Vivian Morafo, PhD*, Kamal Srivastava,

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Genetic susceptibility to food allergy is linked to differential TH2-TH1 responses in C3H/HeJ and BALB/c mice Vivian Morafo, PhD*, Kamal Srivastava, MPhil*, Chih-Kang Huang, MS, Gary Kleiner, MD, PhD, Soo-Young Lee, MD, Hugh A. Sampson, MD, Xiu-Min Li, MD Journal of Allergy and Clinical Immunology Volume 111, Issue 5, Pages 1122-1128 (May 2003) DOI: 10.1067/mai.2003.1463 Copyright © 2003 Mosby, Inc. Terms and Conditions

Fig. 1 A, Levels of serum CM-specific IgE. Sera from each group were collected at several time points after CM-CT sensitization. CM-specific IgE levels were determined by means of ELISA. Data are presented as means ± SEM of each group of mice (n = 5-9). *P < .05 versus BALB/c. B, Plasma histamine levels. Plasma was obtained 30 minutes after CM challenge, and plasma histamine levels were determined by using an enzyme immunoassay kit. Data are presented as means ± SEM. ***P < .001 versus BALB/c mice. Journal of Allergy and Clinical Immunology 2003 111, 1122-1128DOI: (10.1067/mai.2003.1463) Copyright © 2003 Mosby, Inc. Terms and Conditions

Fig. 2 A, Levels of serum peanut-specific IgE. Sera from each group were collected at several time points after peanut-CT sensitization. Peanut-specific IgE levels were determined by meas of ELISA. Data are presented as means ± SEM of each group of mice (n = 5-9). **P < .01 and ***P < .001 versus BALB/c mice. B, Plasma histamine levels. Plasma was obtained 30 minutes after peanut challenge, and plasma histamine levels were determined by using an enzyme immunoassay kit. Data are presented as means ± SEM. ***P < .001 versus BALB/c mice. Journal of Allergy and Clinical Immunology 2003 111, 1122-1128DOI: (10.1067/mai.2003.1463) Copyright © 2003 Mosby, Inc. Terms and Conditions

Fig. 3 Cytokine levels in splenocyte culture supernatants. Immediately after evaluation of anaphylactic reactions, splenocytes were isolated from each group of mice (n = 5) and cultured in the presence of specific antigen. Cells cultured in medium alone or concanavalin A served as negative and positive controls (data not shown). CM-induced IL-4, IFN-γ, and IL-10 levels (A-C) and peanut-induced IL-4, IFN-γ, and IL-10 levels (D-F) were measured by means of ELISA. Data are presented as means ± SEM. ***P Journal of Allergy and Clinical Immunology 2003 111, 1122-1128DOI: (10.1067/mai.2003.1463) Copyright © 2003 Mosby, Inc. Terms and Conditions