The changing distribution of endothelin (ET)A and ETB subtypes with decreasing vessel diameter. a) ET-1 binding and b) distribution of ETA and ETB receptors.

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Presentation transcript:

The changing distribution of endothelin (ET)A and ETB subtypes with decreasing vessel diameter. a) ET-1 binding and b) distribution of ETA and ETB receptors in pulmonary arteries from human subjects (n = 18) are shown. The changing distribution of endothelin (ET)A and ETB subtypes with decreasing vessel diameter. a) ET-1 binding and b) distribution of ETA and ETB receptors in pulmonary arteries from human subjects (n = 18) are shown. Distal arteries possessed more medial [(125)I]-ET-1 binding sites (105±10 versus 45±6 amol·mm−2; p<0.001) and a greater proportion of ETB receptors than proximal arteries (36±3 versus 3±1%; p<0.001). b) ▪: ETA; ░: ETB. ***: p<0.001 versus >8.0 mm external diameter; #: p<0.05 versus 1.0–4.0 mm external diameter; ¶: p<0.05 versus >8.0 mm external diameter. Reproduced and modified from [16] with permission from the publisher. J. Dupuis Eur Respir Rev 2007;16:3-7 ©2007 by European Respiratory Society