Quantitation of H1-receptor antagonists in skin and serum

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Presentation transcript:

Quantitation of H1-receptor antagonists in skin and serum F.Estelle R. Simons, MD, FRCPCa, H.Eileen Murray, MD, FRCPC a, Keith J. Simons, PhDb Journal of Allergy and Clinical Immunology Volume 95, Issue 3, Pages 759-764 (March 1995) DOI: 10.1016/S0091-6749(95)70183-4 Copyright © 1995 Mosby, Inc. Terms and Conditions

FIG. 1 Skin and serum cetirizine concentration versus time plots, and wheal-and-flare areas after epicutaneous tests with 1 and 10 mg/ml histamine. Tests were performed at baseline and 1, 3, 6, 9, and 24 hours after initial dose of 10 mg cetirizine. Subjects then took 10 mg cetirizine at 21:00 hours for 6 consecutive days, and tests were repeated at 168 hours (steady state), exactly 12 hours after seventh and last dose. Journal of Allergy and Clinical Immunology 1995 95, 759-764DOI: (10.1016/S0091-6749(95)70183-4) Copyright © 1995 Mosby, Inc. Terms and Conditions

FIG. 2 Skin and serum hydroxyzine concentrations versus time plots, and wheal-and-flare areas after epicutaneous tests with 1 and 10 mg/ml histamine. Tests were performed at baseline and 1, 3, 6, 9, and 24 hours after initial dose of 50 mg hydroxyzine. Subjects then took 50 mg hydroxyzine at 21:00 hours for 6 consecutive days, and tests were repeated at 168 hours (steady state), exactly 12 hours after seventh and last dose. Journal of Allergy and Clinical Immunology 1995 95, 759-764DOI: (10.1016/S0091-6749(95)70183-4) Copyright © 1995 Mosby, Inc. Terms and Conditions